GNG5 - G protein subunit gamma 5 Gene

中文名称：G 蛋白亚基γ5

种属: Homo sapiens

关于 GNG5

功能概要

蛋白是三聚体 (α-β-γ) 膜相关蛋白，可调节从细胞表面受体到各种内部代谢效应器的信息流。 G 蛋白与其活化受体的相互作用促进 GTP 与 α 亚基结合的 GDP 的交换。 α-GTP 复合物与 β-γ 异二聚体分离，因此亚基反过来可以与效应分子相互作用并调节效应分子 (Gilman，1987 [PubMed 3113327]；Ahmad 等人的总结，1995) [PubMed 7606925]。[OMIM 提供，2010 年 11 月]

G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]