1. Gene
  2. SLC25A6 - solute carrier family 25 member 6 Gene

SLC25A6 - solute carrier family 25 member 6 Gene

中文名称:溶质载体家族 25 成员 6

种属: Homo sapiens

同用名: ANT; AAC3; ANT3; ANT 2; ANT 3; ANT3Y

基因 ID: 293 | 基因类型: protein coding

关于 SLC25A6

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,386,152-1,392,113 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues and 49 paralogues. Ubiquitous expression in kidney (RPKM 238.9), ovary (RPKM 226.6) and 25 other tissues.

功能概要

该基因是溶质载体蛋白基因线粒体载体亚家族的成员。该基因的产物起门控孔的作用,将 ADP 从细胞质转移到线粒体基质中,将 ATP 从线粒体基质转移到细胞质中。该蛋白与通透性转换孔复合体 (PTPC) 的功能有关,PTPC 调节诱导细胞凋亡的线粒体产物的释放。人类基因组包含该基因的几个非转录假基因。[RefSeq 提供,2013 年 6 月]

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce Apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

SLC25A6 基因产物(1)

mRNA Protein Name
NM_001636.4 NP_001627.2 ADP/ATP translocase 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16201016 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
27641616 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC25A6 蛋白结构

Mito_carr

Mito_carr: Mitochondrial carrier protein (6 - 99)

Mito_carr

Mito_carr: Mitochondrial carrier protein (112 - 203)

Mito_carr

Mito_carr: Mitochondrial carrier protein (208 - 297)

  • 0
  • 100
  • 200
  • 298 a.a.
蛋白主名 其他名称

ADP/ATP translocase 3

ADP,ATP carrier protein 3

SLC25A6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC25A6 P12236 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra SLC25A6 P12236 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra SLC25A6 P12236 VDAC1 Homo sapiens P21796
Anti Tag CoIP
21370995
Intra SLC25A6 P12236 AP2B1 Homo sapiens P63010
Validated Y2H
25416956
Intra SLC25A6 P12236 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra SLC25A6 P12236 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra SLC25A6 P12236 TEKT4 Homo sapiens Q8WW24
Validated Y2H
25416956
Intra SLC25A6 P12236 TEKT4 Homo sapiens Q8WW24
Y2H Prey Pooling
25416956
Intra SLC25A6 P12236 TEKT4 Homo sapiens Q8WW24
Y2H Array
25416956
Intra SLC25A6 P12236 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross SLC25A6 P12236 PB1 Influenza A virus P0C0U1
Anti Tag CoIP
16201016
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Bubonic Plague

Black Death

Plague, Bubonic

Plague, Septicemic

Pestis Bubonica

Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLC25A6 VGNC VGNC:49967
Canis familiaris SLC25A6 VGNC VGNC:54600
Rattus norvegicus SLC25A6 RGD RGD:1560896