1. Gene
  2. SNRNP25 - small nuclear ribonucleoprotein U11/U12 subunit 25 Gene

SNRNP25 - small nuclear ribonucleoprotein U11/U12 subunit 25 Gene

中文名称:小核核糖核蛋白 U11/U12 亚基 25

种属: Homo sapiens

同用名: C16orf33

基因 ID: 79622 | 基因类型: protein coding

关于 SNRNP25

This gene has 7 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in brain (RPKM 19.4), heart (RPKM 18.6) and 25 other tissues.

功能概要

两种类型的剪接体催化前体 mRNA 的剪接。主要的 U2 型剪接体存在于所有真核生物中,并去除 U2 型内含子,U2 型内含子占前 mRNA 内含子的 99% 以上。在一些真核生物中发现了较小的 U12 型剪接体,它去除了 U12 型内含子,这种内含子很少见,并且具有明显的剪接一致信号。 U12 型剪接体由几个小核 RNA 和相关蛋白组成。该基因编码一个 25K 的蛋白质,它是 U12 型剪接体的一个组成部分。[RefSeq 提供,2010 年 4 月]

Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

SNRNP25 基因产物(1)

mRNA Protein Name
NM_024571.4 NP_078847.2 U11/U12 small nuclear ribonucleoprotein 25 kDa protein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U12-type spliceosomal complex IDA
IDA: 通过直接分析推断
15146077 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18559850 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

U11/U12 small nuclear ribonucleoprotein 25 kDa protein

U11/U12 snRNP 25 kDa protein

关联疾病

疾病名称 别名
Parosteal Osteosarcoma

Juxtacortical Osteosarcoma

Parosteal Osteogenic Sarcoma

Osteosarcoma, Juxtacortical

Peripheral Osteosarcoma

Surface Osteosarcoma

Bone Surface Osteosarcoma

Li-Fraumeni Syndrome 2

LFS2

Li-Fraumeni Syndrome, Type 2

Li-Fraumeni Syndrome

Li-Fraumeni Syndrome 1

Lfs1

Juxtacortical Chondroma

Periosteal Chondroma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SNRNP25 VGNC VGNC:35069
Felis catus SNRNP25 VGNC VGNC:65533
Mus musculus SNRNP25 MGD MGI:1925622
Canis familiaris SNRNP25 VGNC VGNC:46605
Rattus norvegicus SNRNP25 RGD RGD:1310922