2. Gene
  3. LRRN1 - leucine rich repeat neuronal 1 Gene

LRRN1 - leucine rich repeat neuronal 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富亮氨酸重复神经元 1

种属: Homo sapiens

同用名: NLRR1; NLRR-1; FIGLER3

基因 ID: 57633 | 基因类型: protein coding

关于 LRRN1

Cytogenetic location: 3p26.2 Genomic coordinates (GRCh38): 3:3,799,431-3,849,834 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 25 paralogues. Biased expression in brain (RPKM 12.5), testis (RPKM 4.5) and 8 other tissues.

功能概要

预计在突触组装的正调节上游或正调节内起作用。预计是膜的组成部分。预计在细胞外基质和细胞外空间中具有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRRN1 基因产物(3)

mRNA Protein Name
NM_001324188.2 NP_001311117.1 leucine-rich repeat neuronal protein 1 precursor
NM_001324189.2 NP_001311118.1 leucine-rich repeat neuronal protein 1 precursor
NM_020873.7 NP_065924.3 leucine-rich repeat neuronal protein 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRRN1 蛋白结构

LRR_1

LRR_1: Leucine Rich Repeat (96 - 118)

LRR_8

LRR_8: Leucine rich repeat (120 - 177)

LRR_8

LRR_8: Leucine rich repeat (216 - 275)

LRR_8

LRR_8: Leucine rich repeat (312 - 373)

I-set

I-set: Immunoglobulin I-set domain (431 - 516)

  • 0
  • 200
  • 400
  • 600
  • 716 a.a.
蛋白主名 其他名称

leucine-rich repeat neuronal protein 1

fibronectin type III, immunoglobulin and leucine rich repeat domains 3

LRRN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LRRN1 Q6UXK5 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra LRRN1 Q6UXK5 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Brittle Cornea Syndrome 1

Brittle Cornea Syndrome

Fragilitas Oculi With Joint Hyperextensibility

Dysgenesis Mesodermalis Corneae Et Sclerae

BCS1

Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

Ehlers-Danlos Syndrome, Type Vib, Formerly

Eds6b, Formerly

Type Vib Ehlers-Danlos Syndrome

Eds Vib

Ehlers-Danlos Syndrome Type 6b

Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

Eds6b Formerly

Ehlers-Danlos Syndrome Type Vib Formerly

Ehlers-Danlos Syndrome Type 6

Cornea, Brittle, Syndrome

Cornea, Brittle, Syndrome, Type 1

Ehlers-Danlos Syndrome 6b
Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2
Malignant Inflammatory Fibrous Histiocytoma

Inflammatory Mfh

Xanthosarcoma
Differentiating Neuroblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07836 LRRN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LRRN1 VGNC VGNC:74324
Mus musculus LRRN1 MGD MGI:106038
Felis catus LRRN1 VGNC VGNC:82360
Rattus norvegicus LRRN1 RGD RGD:1564145
Canis familiaris LRRN1 VGNC VGNC:42824
Bos taurus LRRN1 VGNC VGNC:31039
Others LRRN1 NCBI
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