2. Gene
  3. MACIR - macrophage immunometabolism regulator Gene

MACIR - macrophage immunometabolism regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：巨噬细胞免疫代谢调节因子

种属: Homo sapiens

同用名: C5orf30

基因 ID: 90355 | 基因类型: protein coding

关于 MACIR

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:103,258,374-103,278,660 (from NCBI)

This gene has 3 transcripts (splice variants) and 168 orthologues. Broad expression in colon (RPKM 11.1), brain (RPKM 10.1) and 23 other tissues.

功能概要

该基因 MACIR (以前称为 C5orf30) 与类风湿性关节炎有关，作为组织损伤的负调节因子发挥作用，并调节滑膜成纤维细胞和巨噬细胞的活性。编码的蛋白质在脊椎动物基因组中高度保守，但与任何其他人类蛋白质没有显着相似性。[RefSeq 提供，2019 年 12 月]

This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any other human protein. [provided by RefSeq, Dec 2019]

MACIR 基因产物(9)

mRNA Protein Name
NM_001316968.2 NP_001303897.1 macrophage immunometabolism regulator
NM_001316969.2 NP_001303898.1 macrophage immunometabolism regulator
NM_001377283.1 NP_001364212.1 macrophage immunometabolism regulator
NM_001377284.1 NP_001364213.1 macrophage immunometabolism regulator
NM_001377285.1 NP_001364214.1 macrophage immunometabolism regulator
NM_001377286.1 NP_001364215.1 macrophage immunometabolism regulator
NM_001377287.1 NP_001364216.1 macrophage immunometabolism regulator
NM_001377288.1 NP_001364217.1 macrophage immunometabolism regulator
NM_033211.4 NP_149988.1 macrophage immunometabolism regulator
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22085962 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
30659109 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ciliary transition zone IDA
IDA: 通过直接分析推断
22085962 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22085962 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MACIR 蛋白结构

UNC119_bdg

UNC119_bdg: UNC119-binding protein C5orf30 homologue (3 - 200)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

macrophage immunometabolism regulator

UNC119-binding protein C5orf30

MACIR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MACIR Q96GV9 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra MACIR Q96GV9 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra MACIR Q96GV9 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra MACIR Q96GV9 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra MACIR Q96GV9 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra MACIR Q96GV9 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra MACIR Q96GV9 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra MACIR Q96GV9 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra MACIR Q96GV9 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra MACIR Q96GV9 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra MACIR Q96GV9 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07943 MACIR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MACIR RGD RGD:1562136
Canis familiaris MACIR VGNC VGNC:52562
Macaca mulatta MACIR VGNC VGNC:70623
Bos taurus MACIR VGNC VGNC:52734
Mus musculus MACIR MGD MGI:1277184
Felis catus MACIR VGNC VGNC:60247
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