TSSC4 - tumor suppressing subtransferable candidate 4 Gene

中文名称：肿瘤抑制亚转移候选物 4

种属: Homo sapiens

关于 TSSC4

功能概要

该基因是位于 11p15.5 印迹基因域 (一个重要的肿瘤抑制基因区域) 的几个肿瘤抑制亚转移片段之一。该区域的改变与 Beckwith-Wiedemann 综合征、肾母细胞瘤、横纹肌肉瘤、肾上腺皮质癌以及肺癌、卵巢癌和乳腺癌有关。该基因位于几个印迹基因之间；然而，该基因以及泛造血表达基因 (PHEMX) 逃脱了印记。该基因可能在涉及该区域的恶性肿瘤和疾病中发挥作用。已发现该基因编码两种不同亚型的几种转录变体。[RefSeq 提供，2014 年 7 月]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast Cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]