GIT2 - GIT ArfGAP 2 Gene

中文名称：GIT ArfGAP 2

种属: Homo sapiens

同用名: PKL; CAT2; CAT-2

关于 GIT2

功能概要

该基因编码 GIT 蛋白家族的一个成员，该家族与 G 蛋白偶联受体激酶相互作用并具有 ADP 核糖基化因子 (ARF) GTP 酶激活蛋白 (GAP) 活性。 GIT 蛋白在细胞质复合物、粘着斑和细胞外周之间流动，并与 PAK 相互作用交换因子 β (PIX) 相互作用，形成可瞬时募集其他蛋白质的大寡聚复合物。 GIT 蛋白调节细胞骨架动力学并参与受体内化和膜运输。该基因已被证明可以抑制片状足延伸和粘着斑更新，并被认为可以调节细胞运动。该基因经过广泛的可变剪接以产生多种亚型，但其中一些变体的全长性质尚未确定。各种亚型在 ARF GAP 活性和 G 蛋白偶联受体激酶 2 结合方面具有功能差异。[RefSeq 提供，2008 年 9 月]

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with PAK interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit Other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]