TSN - translin Gene

中文名称：转运蛋白

种属: Homo sapiens

同用名: C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1

关于 TSN

功能概要

该基因编码一种 DNA 结合蛋白，可特异性识别染色体易位断点连接处的保守靶序列。易位蛋白多肽形成多聚体结构，负责其 DNA 结合活性。重组相关基序和易位蛋白结合位点存在于重组热点，可作为易位融合基因断点的指标。这些结合活性可能在淋巴肿瘤的染色体易位中起着至关重要的作用。由该基因编码的这种蛋白质，当与转位蛋白相关蛋白 X 复合时，也会形成 Mg 离子依赖性核糖核酸内切酶，促进 RNA 诱导的沉默复合物 (RISC) 激活。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 5 月]

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]