1. Gene
  2. PXN - paxillin Gene

PXN - paxillin Gene

中文名称:桩蛋白

种属: Homo sapiens

基因 ID: 5829 | 基因类型: protein coding

关于 PXN

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,210,447-120,265,730 (from NCBI)

This gene has 22 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 24.8), fat (RPKM 20.4) and 25 other tissues.

功能概要

该基因编码一种细胞骨架蛋白,该蛋白参与细胞粘附到细胞外基质 (粘着斑) 位点的肌动蛋白膜附着。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。这些亚型表现出不同的表达模式,并具有不同的生化和生理特性 (PMID:9054445) 。[RefSeq 提供,2011 年 8 月]

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

PXN 基因产物(15)

mRNA Protein Name
NM_001080855.3 NP_001074324.1 paxillin isoform 2
NM_001243756.2 NP_001230685.1 paxillin isoform 3
NM_001385981.1 NP_001372910.1 paxillin isoform 5
NM_001385982.1 NP_001372911.1 paxillin isoform 6
NM_001385983.1 NP_001372912.1 paxillin isoform 7
NM_001385984.1 NP_001372913.1 paxillin isoform 8
NM_001385985.1 NP_001372914.1 paxillin isoform 9
NM_001385986.1 NP_001372915.1 paxillin isoform 10
NM_001385987.1 NP_001372916.1 paxillin isoform 11
NM_001385988.1 NP_001372917.1 paxillin isoform 12
NM_001385989.1 NP_001372918.1 paxillin isoform 13
NM_001385990.1 NP_001372919.1 paxillin isoform 14
NM_001410986.1 NP_001397915.1 paxillin isoform 15
NM_002859.4 NP_002850.2 paxillin isoform 1
NM_025157.5 NP_079433.3 paxillin isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
17513457 GOA
enables neuropilin binding IPI
IPI: 通过物理相互作用推断
24863063 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7561682 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
28759036 GOA
enables vinculin binding IPI
IPI: 通过物理相互作用推断
9054445 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IMP
IMP: 通过突变表型推断
23275153 GOA
involved in cellular response to reactive oxygen species IEP
IEP: 通过表达模式推断
12686598 GOA
involved in endothelial cell migration IMP
IMP: 通过突变表型推断
24863063 GOA
involved in growth hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
10925297 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
24863063 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
24036928 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IMP
IMP: 通过突变表型推断
25753039 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
12686598 GOA
located in focal adhesion IMP
IMP: 通过突变表型推断
25705373 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
12686598 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17449030 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
24036928 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PXN 蛋白结构

Paxillin

Paxillin: Paxillin family (44 - 253)

LIM

LIM: LIM domain (358 - 412)

LIM

LIM: LIM domain (417 - 472)

LIM

LIM: LIM domain (476 - 530)

LIM

LIM: LIM domain (535 - 590)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
蛋白主名 其他名称

paxillin

testicular tissue protein Li 134

PXN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PXN P49023 GIT2 Homo sapiens Q14161 22728435
种属内
PXN P49023 GIT2 Homo sapiens Q14161 31980649
种属内
PXN P49023 CSK Homo sapiens P41240 14665621
种属内
PXN P49023 PTPN12 Homo sapiens Q05209 35271311
种属内
PXN P49023 PTPN11 Homo sapiens Q06124 14665621
种属内
PXN P49023 PTPN11 Homo sapiens Q06124
PLA
23397142
种属内
PXN P49023 RNF5 Homo sapiens Q99942 12861019
种属内
PXN P49023 RNF5 Homo sapiens Q99942 12861019
种属内
PXN P49023 RNF5 Homo sapiens Q99942 12861019
种属内
PXN P49023 GIT1 Homo sapiens Q9Y2X7 31980649
种属内
PXN P49023 GIT1 Homo sapiens Q9Y2X7 16628223
种属内
PXN P49023 CTNNB1 Homo sapiens P35222 22728435
种属内
PXN P49023 GAB1 Homo sapiens Q13480 14665621
种属内
PXN P49023 PTK2 Homo sapiens Q05397 21034468
种属内
PXN P49023 PTK2 Homo sapiens Q05397 31980649
种属内
PXN P49023 PTK2 Homo sapiens Q05397 9756887
种属内
PXN P49023 PTK2 Homo sapiens Q05397 25795725
种属内
PXN P49023 PTK2 Homo sapiens Q05397
IF
22270917
种属内
PXN P49023 PTK2 Homo sapiens Q05397 21741599
种属内
PXN P49023 PTK2 Homo sapiens Q05397 7561682
种属内
PXN P49023 PTK2 Homo sapiens Q05397 22270917
种属内
PXN P49023 ITGA4 Homo sapiens P13612 10604475
种属内
PXN P49023 ITGA4 Homo sapiens P13612 10604475
种属间
PXN P49023 Sorbs1 Mus musculus Q62417-2 17082770
种属间
PXN P49023 Sorbs1 Mus musculus Q62417-2 17082770
种属间
PXN P49023 E6 Bovine papillomavirus P06931 10814581
种属间
PXN P49023 rnf-5 Caenorhabditis elegans Q09463 12861019
种属间: 跨种属相互作用 种属内: 同种属相互作用

PXN 抗体

目录号 产品名 应用 反应物种
HY-P83338 Phospho-Paxillin (Tyr118) Antibody (YA3083) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Acoustic Neurinoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PXN VGNC VGNC:107261
Canis familiaris PXN VGNC VGNC:52959
Mus musculus PXN MGD MGI:108295
Felis catus PXN VGNC VGNC:80471
Rattus norvegicus PXN RGD RGD:1305759
Macaca mulatta PXN VGNC VGNC:76629
Macaca fascicularis PXN NCBI NCBI:102138249
Others PXN NCBI