2. Gene
  3. Arhgef7 - Rho guanine nucleotide exchange factor (GEF7) Gene

Arhgef7 - Rho guanine nucleotide exchange factor (GEF7) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; beta-Pix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142

基因 ID: 54126 | 基因类型: protein coding

关于 Arhgef7

功能概要

Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; positive regulation of GTPase activity; and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including metanephros; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef7 基因产物(9)

mRNA Protein Name
NM_001113517.2 NP_001106989.1 rho guanine nucleotide exchange factor 7 isoform a
NM_001113518.2 NP_001106990.1 rho guanine nucleotide exchange factor 7 isoform b
NM_001372321.1 NP_001359250.1 rho guanine nucleotide exchange factor 7 isoform d
NM_001372322.1 NP_001359251.1 rho guanine nucleotide exchange factor 7 isoform e
NM_001372323.1 NP_001359252.1 rho guanine nucleotide exchange factor 7 isoform f
NM_001372324.1 NP_001359253.1 rho guanine nucleotide exchange factor 7 isoform c
NM_001372325.1 NP_001359254.1 rho guanine nucleotide exchange factor 7 isoform g
NM_001372326.1 NP_001359255.1 rho guanine nucleotide exchange factor 7 isoform h
NM_017402.5 NP_059098.2 rho guanine nucleotide exchange factor 7 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
21828338 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10428811 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
21048939 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: 通过遗传相互作用推断
24029230 MGI
involved in lamellipodium assembly IMP
IMP: 通过突变表型推断
18325335 MGI
acts upstream of or within positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
21828338 MGI
acts upstream of or within positive regulation of growth hormone secretion IMP
IMP: 通过突变表型推断
21828338 MGI
acts upstream of or within positive regulation of protein binding IMP
IMP: 通过突变表型推断
21828338 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
21828338 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
18325335 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
21828338 MGI
located in postsynapse IDA
IDA: 通过直接分析推断
24297929 MGI
located in storage vacuole IDA
IDA: 通过直接分析推断
21828338 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

rho guanine nucleotide exchange factor 7

PAK-interacting exchange factor beta

Pak3 binding protein

Arhgef7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Arhgef7 Q9ES28 GIT2 Homo sapiens Q14161
Pull Down
21295525
种属间
Arhgef7 Q9ES28 PARVB Homo sapiens Q9HBI1
Pull Down
18325335
种属内
Arhgef7 Q9ES28 Git2 Mus musculus Q9JLQ2
Y2H
15102471
种属内
Arhgef7 Q9ES28 Parvb Mus musculus Q9ES46
Anti Tag CoIP
24035453
种属间
Arhgef7 Q9ES28 Shank2 Rattus norvegicus Q9QX74-4
Pull Down
20080968
种属间
Arhgef7 Q9ES28 Shank2 Rattus norvegicus Q9QX74-4
Anti Bait CoIP
20080968
种属间
Arhgef7 Q9ES28 Shank2 Rattus norvegicus Q9QX74-4
Crosslink
20080968
种属间
Arhgef7 Q9ES28 Git1 Rattus norvegicus Q9Z272
Pull Down
21295525
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00964 ARHGEF7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Arhgef7 NCBI NCBI:8874
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