PARVB - parvin beta Gene

中文名称：帕文贝塔

种属: Homo sapiens

同用名: CGI-56

关于 PARVB

功能概要

该基因编码肌动蛋白结合蛋白 parvin 家族的一个成员，该蛋白在细胞骨架组织和细胞粘附中发挥作用。这些蛋白质与焦点接触相关，并包含与肌动蛋白丝结合的钙调蛋白同源结构域。该家族成员与 alphaPIX 和 alpha-actinin 结合，可抑制整合素连接激酶的活性。这种蛋白质还在肿瘤抑制中发挥作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the parvin family of actin-binding proteins, which play a role in Cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]