ARHGEF7 - Rho guanine nucleotide exchange factor 7 Gene

中文名称：Rho 鸟嘌呤核苷酸交换因子 7

种属: Homo sapiens

同用名: P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314

关于 ARHGEF7

功能概要

该基因编码的蛋白质属于细胞质蛋白家族，通过将结合的 GDP 交换为 GTP 来激活 Rho 蛋白的 Ras 样家族。它与小 GTP 结合蛋白 Rac1 形成复合物，并将 Rac1 募集到膜褶皱和粘着斑。已对该基因观察到编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]