PAK2 - p21 (RAC1) activated kinase 2 Gene

中文名称：p21 (RAC1) 激活激酶 2

种属: Homo sapiens

同用名: KNO2; PAK65; PAKgamma

基因 ID: 5062 | 基因类型: protein coding

关于 PAK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,739,857-196,832,647 (from NCBI)

This gene has 3 transcripts (splice variants), 293 orthologues and 35 paralogues. Ubiquitous expression in spleen (RPKM 22.2), appendix (RPKM 21.0) and 25 other tissues.

功能概要

p21 活化激酶 (PAK) 是将 Rho GTP 酶与细胞骨架重组和核信号转导联系起来的关键效应物。 PAK 蛋白是一个丝氨酸/苏氨酸激酶家族，可作为小 GTP 结合蛋白、CDC42 和 RAC1 的靶标，并涉及广泛的生物活性。由该基因编码的蛋白质在半胱天冬酶介导的细胞凋亡过程中被蛋白水解切割激活，并可能在调节垂死细胞的细胞凋亡事件中发挥作用。[RefSeq 提供，2008 年 7 月]

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to Cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated Apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

PAK2 基因产物(4)

mRNA	Protein	Name
XM_047448219.1	XP_047304175.1	serine/threonine-protein kinase PAK 2 isoform X1
XM_011512870.3	XP_011511172.1	serine/threonine-protein kinase PAK 2 isoform X1
NM_002577.4	NP_002568.2	serine/threonine-protein kinase PAK 2
XM_047448218.1	XP_047304174.1	serine/threonine-protein kinase PAK 2 isoform X1

PAK2 蛋白结构

PBD

Pkinase

0
100
200
300
400
524 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase PAK 2

PAK-2	S6/H4 kinase
gamma-PAK	p21 (CDKN1A)-activated kinase 2
p21 protein (Cdc42/Rac)-activated kinase 2	p21-activated kinase 2
p58

PAK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Pull Down	32707033
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Pull Down	22705156
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Y2H Prey Pooling	25416956
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Pull Down	19264842
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Validated Y2H	32296183
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Pull Down	32707033
Intra	PAK2	Q13177	RAC1	Homo sapiens	P63000	Solid Phase Assay	20696164
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Anti Bait CoIP	17353931
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Y2H Array	32296183
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Filter Binding	16374509
Intra	PAK2	Q13177	ARHGEF6	Homo sapiens	Q15052	Anti Tag CoIP	35271311
Intra	PAK2	Q13177	CDC42	Homo sapiens	P60953	Y2H Array	32296183
Intra	PAK2	Q13177	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PAK2	Q13177	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PAK2	Q13177	HCK	Homo sapiens	P08631	Filter Binding	16374509
Intra	PAK2	Q13177	NCK1	Homo sapiens	P16333	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	NCK1	Homo sapiens	P16333	Y2H Array	32296183
Intra	PAK2	Q13177	SORBS1	Homo sapiens	Q9BX66	Filter Binding	16374509
Intra	PAK2	Q13177	LIMK1	Homo sapiens	P53667	Protein Kinase Assay	16837009
Intra	PAK2	Q13177	HTT	Homo sapiens	P42858	Anti Tag CoIP	19240112
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Protein Kinase Assay	21555521
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Anti Bait CoIP	21555521
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Confocal	21555521
Intra	PAK2	Q13177	CASP7	Homo sapiens	P55210	Anti Tag CoIP	21555521
Intra	PAK2	Q13177	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	32296183
Intra	PAK2	Q13177	RHOJ	Homo sapiens	Q9H4E5	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	RHOJ	Homo sapiens	Q9H4E5	Y2H Array	32296183
Intra	PAK2	Q13177	NCK2	Homo sapiens	O43639	Anti Tag CoIP	35271311
Intra	PAK2	Q13177	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	PAK2	Q13177	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	PAK2	Q13177	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	16787945
Intra	PAK2	Q13177	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	35271311
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Filter Binding	16374509
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	25416956
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Validated Y2H	25416956
Intra	PAK2	Q13177	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
Cross	PAK2	Q13177	Arhgef7	Rattus norvegicus	O55043	ITC	16527308

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Knobloch Syndrome 2

KNO2	Knobloch Syndrome, Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Knobloch Syndrome 1

Retinal Detachment And Occipital Encephalocele	Knobloch Syndrome, Type 1
KNO1	Kno
Knobloch Syndrome

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency	Glucose-6-Phosphate Dehydrogenase Deficiency
Deficiency Of Glucose-6-Phosphate Dehydrogenase	Glucose 6 Phosphate Dehydrogenase Deficiency
Deficiency Of G-6pd	G6pdd

Knobloch Syndrome

Knobloch-Layer Syndrome	Retinal Detachment-Occipital Encephalocele Syndrome
Myopia Retinal Detachment Encephalocele	Retinal Detachment And Occipital Encephalocele

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15542A	FRAX597	Inhibitor	99.79%	否
HY-15542B	FRAX486	Inhibitor	98.01%	否
HY-19635	G-5555	Inhibitor	99.88%	否
HY-19538	FRAX1036	Inhibitor	99.49%	否
HY-120940	AZ13705339	Inhibitor	98.90%	否
HY-19635A	G-5555 hydrochloride	Inhibitor	98.78%	否
HY-131043	NVS-PAK1-C	Inhibitor	≥99.0%	否
HY-120940A	AZ13705339 hemihydrate	Inhibitor	99.77%	否
HY-146786	ZMF-10	Inhibitor	/	否
HY-116917	G-9791	Inhibitor	/	否
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	否
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PAK2	MGD	MGI:1339984
Bos taurus	PAK2	VGNC	VGNC:53593
Macaca mulatta	PAK2	VGNC	VGNC:84053
Canis familiaris	PAK2	VGNC	VGNC:53081
Felis catus	PAK2	VGNC	VGNC:102796
Rattus norvegicus	PAK2	RGD	RGD:61953
Others	PAK2	NCBI

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