RHOJ - ras homolog family member J Gene

中文名称：ras 同系物家族成员 J

种属: Homo sapiens

同用名: TCL; ARHJ; TC10B; RASL7B

基因 ID: 57381 | 基因类型: protein coding

关于 RHOJ

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,204,443-63,293,508 (from NCBI)

This gene has 4 transcripts (splice variants), 149 orthologues and 22 paralogues. Ubiquitous expression in gall bladder (RPKM 9.9), lung (RPKM 9.2) and 23 other tissues.

功能概要

该基因编码 Rho 家族中的许多小 GTP 结合蛋白之一，显示与内皮细胞粘着斑有关 (PMID：21148427、22103495) 。编码的蛋白质被血管内皮生长因子激活，可以调节血管生成。[RefSeq 提供，2011 年 12 月]

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]

RHOJ 基因产物(1)

mRNA	Protein	Name
NM_020663.5	NP_065714.1	rho-related GTP-binding protein RhoJ

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTP binding	IDA IDA: 通过直接分析推断	27660391	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	27660391	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin cytoskeleton organization	IMP IMP: 通过突变表型推断	10967094	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	28727754	GOA
involved in regulation of endothelial cell migration	IMP IMP: 通过突变表型推断	30158707	GOA
involved in regulation of sprouting angiogenesis	IMP IMP: 通过突变表型推断	21628409	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	27660391	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RHOJ 蛋白结构

Ras

0
100
200
214 a.a.

蛋白主名

其他名称

rho-related GTP-binding protein RhoJ

RAS-like, family 7, member B

RHOJ 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RHOJ	Q9H4E5	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	SSX3	Homo sapiens	Q99909	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	SSX3	Homo sapiens	Q99909	Anti Tag CoIP	25416956
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Anti Tag CoIP	33961781
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	PAK2	Homo sapiens	Q13177	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	PAK6	Homo sapiens	Q9NQU5	Y2H Array	31515488
Intra	RHOJ	Q9H4E5	PAK6	Homo sapiens	Q9NQU5	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Anti Tag CoIP	33961781
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	PAK1	Homo sapiens	Q13153	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	PAK3	Homo sapiens	O75914-2	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	PAK3	Homo sapiens	O75914-2	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	33961781
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	PARD6B	Homo sapiens	Q9BYG5	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	CRYAA	Homo sapiens	P02489	Y2H Array	32814053
Intra	RHOJ	Q9H4E5	CRYAA	Homo sapiens	P02489	Y2H Pooling	32814053
Intra	RHOJ	Q9H4E5	CRYAA	Homo sapiens	P02489	Validated Y2H	32814053
Intra	RHOJ	Q9H4E5	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	TRIP10	Homo sapiens	Q15642	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	TRIP10	Homo sapiens	Q15642	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	PAK5	Homo sapiens	Q9P286	Validated Y2H	32296183
Intra	RHOJ	Q9H4E5	PAK5	Homo sapiens	Q9P286	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	RHOJ	Q9H4E5	CDC42EP1	Homo sapiens	Q00587	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	GLUL	Homo sapiens	P15104	Anti Bait CoIP	30158707
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Validated Y2H	25416956
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Prey Pooling	25416956
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Array	25416956
Intra	RHOJ	Q9H4E5	WASL	Homo sapiens	O00401	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Parasitic Ichthyosporea Infectious Disease

Rhinosporidiosis

Infection By Rhinosporidium Seeberi

Rhinosporosis

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11955	RHOJ Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-167828	ARN25062	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RHOJ	VGNC	VGNC:76885
Felis catus	RHOJ	VGNC	VGNC:80867
Bos taurus	RHOJ	VGNC	VGNC:33951
Canis familiaris	RHOJ	VGNC	VGNC:45562
Rattus norvegicus	RHOJ	RGD	RGD:1310528
Mus musculus	RHOJ	MGD	MGI:1931551

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