2. Gene
  3. PARD6B - par-6 family cell polarity regulator beta Gene

PARD6B - par-6 family cell polarity regulator beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：par-6 系列细胞极性调节因子 beta

种属: Homo sapiens

同用名: PAR6B

基因 ID: 84612 | 基因类型: protein coding

关于 PARD6B

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,731,580-50,753,741 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues and 2 paralogues. Broad expression in kidney (RPKM 9.5), lung (RPKM 3.4) and 17 other tissues.

功能概要

该基因是 PAR6 家族的成员，编码的蛋白质具有 PSD95/Discs-large/ZO1 (PDZ) 结构域、OPR 结构域和半 Cdc42/Rac 交互结合 (CRIB) 结构域。这种细胞质蛋白作为多蛋白复合物的成员参与不对称细胞分裂和细胞极化过程。[RefSeq 提供，2008 年 7 月]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

PARD6B 基因产物(1)

mRNA Protein Name
NM_032521.3 NP_115910.1 partitioning defective 6 homolog beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11260256 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein-containing complex assembly IDA
IDA: 通过直接分析推断
12545177 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
12545177 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12545177 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARD6B 蛋白结构

PB1

PB1: PB1 domain (16 - 95)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (158 - 238)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
蛋白主名 其他名称

partitioning defective 6 homolog beta

PAR-6 beta

PARD6B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PARD6B Q9BYG5 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra PARD6B Q9BYG5 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra PARD6B Q9BYG5 FRMD6 Homo sapiens Q96NE9-2
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 FRMD6 Homo sapiens Q96NE9-2
Y2H Array
32296183
Intra PARD6B Q9BYG5 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32296183
Intra PARD6B Q9BYG5 CDCA4 Homo sapiens Q9BXL8
Y2H Array
32296183
Intra PARD6B Q9BYG5 CDCA4 Homo sapiens Q9BXL8
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra PARD6B Q9BYG5 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 RASSF3 Homo sapiens Q86WH2
Y2H Array
32296183
Intra PARD6B Q9BYG5 RASSF3 Homo sapiens Q86WH2
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
33961781
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Array
32296183
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
28514442
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Prey Pooling
25416956
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
14676191
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
26496610
Intra PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Array
25416956
Intra PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Pull Down
11260256
Intra PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
33961781
Intra PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Y2H Array
32296183
Intra PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
28514442
Intra PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
14676191
Intra PARD6B Q9BYG5 YWHAH Homo sapiens Q04917
Anti Tag CoIP
26496610
Intra PARD6B Q9BYG5 YWHAH Homo sapiens Q04917
Anti Tag CoIP
14676191
Intra PARD6B Q9BYG5 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra PARD6B Q9BYG5 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra PARD6B Q9BYG5 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra PARD6B Q9BYG5 RHOJ Homo sapiens Q9H4E5
Y2H Prey Pooling
25416956
Intra PARD6B Q9BYG5 RHOJ Homo sapiens Q9H4E5
Validated Y2H
32296183
Intra PARD6B Q9BYG5 RHOQ Homo sapiens P17081
Y2H Array
32296183
Intra PARD6B Q9BYG5 RHOQ Homo sapiens P17081
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra PARD6B Q9BYG5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 ZSCAN4 Homo sapiens Q8NAM6
Y2H Array
32296183
Intra PARD6B Q9BYG5 ZSCAN4 Homo sapiens Q8NAM6
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Array
25416956
Intra PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
Intra PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra PARD6B Q9BYG5 MAGOHB Homo sapiens Q96A72
Y2H Array
32296183
Intra PARD6B Q9BYG5 MAGOHB Homo sapiens Q96A72
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 RAC3 Homo sapiens P60763
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 RAC3 Homo sapiens P60763
Y2H Array
32296183
Intra PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Array
32296183
Intra PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Prey Pooling
25416956
Intra PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Anti Tag CoIP
14676191
Intra PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Array
25416956
Intra PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Prey Pooling
32296183
Intra PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Pooling
20936779
Intra PARD6B Q9BYG5 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
33961781
Intra PARD6B Q9BYG5 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
26496610
Intra PARD6B Q9BYG5 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
14676191
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10039 PARD6B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PARD6B VGNC VGNC:107850
Rattus norvegicus PARD6B RGD RGD:1308205
Canis familiaris PARD6B VGNC VGNC:54725
Bos taurus PARD6B VGNC VGNC:32584
Mus musculus PARD6B MGD MGI:2135605
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z