RHOQ - ras homolog family member Q Gene

中文名称：ras 同系物家族成员 Q

种属: Homo sapiens

同用名: ARHQ; TC10; TC10A; RASL7A; HEL-S-42

关于 RHOQ

功能概要

该基因编码小 GTP 酶 Rho 家族的一个成员，它在非活性 GDP 结合状态和活性 GTP 结合状态之间循环，并在信号转导级联中充当分子开关。 Rho 蛋白促进肌动蛋白细胞骨架的重组并调节细胞形状、附着和运动。编码的蛋白质是肌节组装的重要信号蛋白，已被证明在溶质载体家族 2、促进葡萄糖转运蛋白成员 4 和其他蛋白质的胞吐作用中发挥重要作用，可能作为开启膜融合的信号机械。已在 2 号和 14 号染色体上鉴定出三个相关的假基因。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]