2. Gene
  3. PRKCZ - protein kinase C zeta Gene

PRKCZ - protein kinase C zeta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 Czeta

种属: Homo sapiens

同用名: PKC2; PKC-ZETA

基因 ID: 5590 | 基因类型: protein coding

关于 PRKCZ

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:2,048,504-2,185,395 (from NCBI)

This gene has 26 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues.

功能概要

蛋白激酶 C (PKC) zeta 是 PKC 丝氨酸/苏氨酸激酶家族的成员，参与多种细胞过程，例如增殖、分化和分泌。与依赖钙的经典 PKC 同工酶不同，PKC zeta 表现出不依赖于钙和甘油二酯但不依赖于磷脂酰丝氨酸的激酶活性。此外，它对典型的 PKC 抑制剂不敏感，不能被佛波酯激活。与经典的 PKC 同工酶不同，它只有一个锌指模块。这些结构和生化特性表明 zeta 亚种与 PKC 的其他同工酶相关但不同。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKCZ 基因产物(35)

mRNA Protein Name
NR_146911.2
XM_017001789.2 XP_016857278.1 protein kinase C zeta type isoform X1
XM_024448396.2 XP_024304164.1 protein kinase C zeta type isoform X14
XM_011541776.2 XP_011540078.1 protein kinase C zeta type isoform X14
XR_007061965.1
XR_007061966.1
XM_017001803.3 XP_016857292.1 protein kinase C zeta type isoform X18
XM_024448397.2 XP_024304165.1 protein kinase C zeta type isoform X16
NM_001350805.2 NP_001337734.1 protein kinase C zeta type isoform 5
XM_017001793.2 XP_016857282.1 protein kinase C zeta type isoform X10
XM_047425273.1 XP_047281229.1 protein kinase C zeta type isoform X7
XM_047425260.1 XP_047281216.1 protein kinase C zeta type isoform X5
XM_047425262.1 XP_047281218.1 protein kinase C zeta type isoform X6
XM_011541775.4 XP_011540077.1 protein kinase C zeta type isoform X13
XM_047425304.1 XP_047281260.1 protein kinase C zeta type isoform X10
XM_017001802.2 XP_016857291.1 protein kinase C zeta type isoform X17
NM_001242874.3 NP_001229803.1 protein kinase C zeta type isoform 3
XM_017001797.2 XP_016857286.1 protein kinase C zeta type isoform X12
XM_047425348.1 XP_047281304.1 protein kinase C zeta type isoform X15
NM_001350803.2 NP_001337732.1 protein kinase C zeta type isoform 4
XM_047425323.1 XP_047281279.1 protein kinase C zeta type isoform X11
XM_024448391.2 XP_024304159.1 protein kinase C zeta type isoform X10
XM_017001792.2 XP_016857281.1 protein kinase C zeta type isoform X10
XM_017001790.2 XP_016857279.1 protein kinase C zeta type isoform X2
XM_047425307.1 XP_047281263.1 protein kinase C zeta type isoform X10
XM_011541773.2 XP_011540075.1 protein kinase C zeta type isoform X3
XM_047425340.1 XP_047281296.1 protein kinase C zeta type isoform X14
XM_047425255.1 XP_047281211.1 protein kinase C zeta type isoform X4
XM_011541774.2 XP_011540076.1 protein kinase C zeta type isoform X8
XM_047425283.1 XP_047281239.1 protein kinase C zeta type isoform X9
NM_001033581.3 NP_001028753.1 protein kinase C zeta type isoform 2
NM_001350806.2 NP_001337735.1 protein kinase C zeta type isoform 5
NM_001033582.3 NP_001028754.1 protein kinase C zeta type isoform 2
NM_002744.6 NP_002735.3 protein kinase C zeta type isoform 1
NM_001350804.2 NP_001337733.1 protein kinase C zeta type isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: 通过实验结果推断
12391145 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10831594 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
10770950 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
15069075 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
15069075 GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
15069075 GOA
involved in negative regulation of protein-containing complex assembly IMP
IMP: 通过突变表型推断
15069075 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
15069075 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
11035106 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10770950 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
20332120 GOA
located in vesicle IDA
IDA: 通过直接分析推断
17313651 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCZ 蛋白结构

PB1

PB1: PB1 domain (16 - 97)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (131 - 182)

Pkinase

Pkinase: Protein kinase domain (253 - 503)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (540 - 583)

  • 0
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  • 500
  • 592 a.a.
蛋白主名 其他名称

protein kinase C zeta type

nPKC-zeta

PRKCZ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRKCZ Q05513 AGER Homo sapiens Q15109
Anti Bait CoIP
21829704
Intra PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Tag CoIP
33961781
Intra PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Bait CoIP
24375676
Intra PRKCZ Q05513 PRKCI Homo sapiens P41743
CoIP
11260256
Intra PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Tag CoIP
28514442
Intra PRKCZ Q05513 PRKCI Homo sapiens P41743
Pull Down
32707033
Intra PRKCZ Q05513 PRKCI Homo sapiens P41743
Anti Tag CoIP
25852190
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Pull Down
32707033
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
CoIP
11260256
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Validated Y2H
27107012
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Y2H
11260256
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Anti Tag CoIP
31980649
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
BFG-2H
27107012
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra PRKCZ Q05513 PARD6B Homo sapiens Q9BYG5
Anti Tag CoIP
25852190
Intra PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
17057644
Intra PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
31980649
Intra PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
25852190
Intra PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
33961781
Intra PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Pull Down
32707033
Intra PRKCZ Q05513 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
28514442
Intra PRKCZ Q05513 AKT1 Homo sapiens P31749
Anti Bait CoIP
18650932
Intra PRKCZ Q05513 VHL Homo sapiens P40337
Anti Tag CoIP
17350623
Intra PRKCZ Q05513 C1QBP Homo sapiens Q07021
Anti Tag CoIP
25852190
Intra PRKCZ Q05513 C1QBP Homo sapiens Q07021
Anti Tag CoIP
31980649
Intra PRKCZ Q05513 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Intra PRKCZ Q05513 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra PRKCZ Q05513 PRKCQ Homo sapiens Q04759
Anti Bait CoIP
17588663
Intra PRKCZ Q05513 PRKCQ Homo sapiens Q04759
Protein Kinase Assay
17588663
Intra PRKCZ Q05513 NCF1 Homo sapiens P14598
Pull Down
27040869
Intra PRKCZ Q05513 NCF1 Homo sapiens P14598
Anti Bait CoIP
27040869
Intra PRKCZ Q05513 NUMB Homo sapiens P49757-1
Anti Tag CoIP
17203073
Intra PRKCZ Q05513 NUMB Homo sapiens P49757-1
Pull Down
17203073
Intra PRKCZ Q05513 NUMB Homo sapiens P49757-1
Protein Kinase Assay
17203073
Intra PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
17057644
Intra PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Y2H
11260256
Intra PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
25852190
Intra PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Anti Tag CoIP
33961781
Intra PRKCZ Q05513 PARD6A Homo sapiens Q9NPB6
Y2H Pooling
16189514
Intra PRKCZ Q05513 BCL10 Homo sapiens O95999
Anti Bait CoIP
25011391
Intra PRKCZ Q05513 BCL10 Homo sapiens O95999
PLA
25011391
Intra PRKCZ Q05513 BCL10 Homo sapiens O95999
Confocal
25011391
Cross PRKCZ Q05513 numb Drosophila melanogaster P16554
Protein Kinase Assay
17203073
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diabetes Mellitus

Diabetes
Combined Oxidative Phosphorylation Deficiency 33

COXPD33
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11141 PRKCZ Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11142 Prkcz Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11143 Prkcz Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PRKCZ VGNC VGNC:33336
Felis catus PRKCZ VGNC VGNC:80323
Mus musculus PRKCZ MGD MGI:97602
Macaca mulatta PRKCZ VGNC VGNC:82212
Rattus norvegicus PRKCZ RGD RGD:3399
Canis familiaris PRKCZ VGNC VGNC:44985
Others PRKCZ NCBI
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