2. Gene
  3. PRKCQ - protein kinase C theta Gene

PRKCQ - protein kinase C theta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 Cθ

种属: Homo sapiens

同用名: PRKCT; nPKC-theta

基因 ID: 5588 | 基因类型: protein coding

关于 PRKCQ

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,394,097-6,580,646 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 5 paralogues. Broad expression in thyroid (RPKM 4.0), lymph node (RPKM 2.9) and 17 other tissues.

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯 (一类肿瘤促进剂) 的主要受体。 PKC 家族的每个成员都有特定的表达谱，并被认为发挥着独特的作用。该基因编码的蛋白质是 PKC 家族成员之一。它是一种钙非依赖性和磷脂依赖性蛋白激酶。这种激酶对 T 细胞活化很重要。它是激活转录因子 NF-kappaB 和 AP-1 所必需的，并且可能将 T 细胞受体 (TCR) 信号复合物与转录因子的激活联系起来。[RefSeq 提供，2008 年 7 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]

PRKCQ 基因产物(9)

mRNA Protein Name
NM_001323267.2 NP_001310196.1 protein kinase C theta type isoform 5
NM_001323265.1 NP_001310194.1 protein kinase C theta type isoform 1
NM_006257.5 NP_006248.1 protein kinase C theta type isoform 1
NM_001282645.1 NP_001269574.1 protein kinase C theta type isoform 4
XM_005252496.5 XP_005252553.1 protein kinase C theta type isoform X1
NM_001242413.2 NP_001229342.1 protein kinase C theta type isoform 2
XM_005252497.5 XP_005252554.1 protein kinase C theta type isoform X2
NM_001282644.2 NP_001269573.1 protein kinase C theta type isoform 3
NM_001323266.2 NP_001310195.1 protein kinase C theta type isoform 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: 通过实验结果推断
16356856 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10383400 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
34593629 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
24008408 GOA
involved in negative regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
11342610 GOA
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
15364919 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
16356855 GOA
acts upstream of or within positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
21531765 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
34593629 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCQ 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (160 - 210)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (232 - 283)

Pkinase

Pkinase: Protein kinase domain (382 - 633)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (654 - 699)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
蛋白主名 其他名称

protein kinase C theta type

PRKCQ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRKCQ Q04759 LCK Homo sapiens P06239
Anti Tag CoIP
21964608
Intra PRKCQ Q04759 MAP4K3 Homo sapiens Q8IVH8
Pull Down
21983831
Intra PRKCQ Q04759 PRKCZ Homo sapiens Q05513
Y2H
17588663
Intra PRKCQ Q04759 GLRX3 Homo sapiens O76003
CoIP
10636891
Intra PRKCQ Q04759 GLRX3 Homo sapiens O76003
Pull Down
10636891
Intra PRKCQ Q04759 FYN Homo sapiens P06241
Protein Kinase Assay
10383400
Intra PRKCQ Q04759 FYN Homo sapiens P06241
Pull Down
10383400
Intra PRKCQ Q04759 FYN Homo sapiens P06241
Y2H
10383400
Intra PRKCQ Q04759 HSF1 Homo sapiens Q00613
Anti Bait CoIP
23352416
Cross PRKCQ Q04759 Irs1 Rattus norvegicus P35570
Protein Kinase Assay
23352416
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma
Ciliary Dyskinesia, Primary, 20

Primary Ciliary Dyskinesia 20

CILD20

Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus

Ics20

Immotile Cilia Syndrome 20

Dyskinesia, Ciliary, Primary, 20
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Enteritis, Granulomatous

Crohn'S Disease Of Colon

Granulomatous Colitis

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Enteritis

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11137 PRKCQ Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11138 Prkcq Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11139 Prkcq Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRKCQ MGD MGI:97601
Felis catus PRKCQ VGNC VGNC:69067
Canis familiaris PRKCQ VGNC VGNC:44983
Rattus norvegicus PRKCQ RGD RGD:620968
Macaca mulatta PRKCQ VGNC VGNC:76416
Bos taurus PRKCQ VGNC VGNC:33334
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