2. Gene
  3. MAP4K3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

MAP4K3 - mitogen-activated protein kinase kinase kinase kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 3

种属: Homo sapiens

同用名: GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1

基因 ID: 8491 | 基因类型: protein coding

关于 MAP4K3

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:39,249,266-39,437,285 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 35 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), testis (RPKM 13.3) and 25 other tissues.

功能概要

该基因编码丝裂原活化蛋白激酶激酶激酶激酶家族的成员。编码的蛋白质激活细胞信号传导中的关键效应物，其中包括 c-Jun。已经观察到该基因编码多种亚型的可变剪接转录物。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

MAP4K3 基因产物(7)

mRNA Protein Name
NM_003618.4 NP_003609.2 mitogen-activated protein kinase kinase kinase kinase 3 isoform 1
XM_024453183.2 XP_024308951.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X4
XM_047446093.1 XP_047302049.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X3
NM_001410753.1 NP_001397682.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 3
XM_047446092.1 XP_047302048.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X2
XM_047446091.1 XP_047302047.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform X1
NM_001270425.2 NP_001257354.1 mitogen-activated protein kinase kinase kinase kinase 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9275185 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9275185 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9275185 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9275185 GOA
involved in response to UV IDA
IDA: 通过直接分析推断
9275185 GOA
involved in response to tumor necrosis factor IDA
IDA: 通过直接分析推断
9275185 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP4K3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (16 - 273)

CNH

CNH: CNH domain (567 - 864)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 894 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase kinase 3

MAPK/ERK kinase kinase kinase 3

MEK kinase kinase 3

germinal center kinase-like kinase

germinal center kinase-related protein kinase

MAP4K3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MAP4K3 Q8IVH8 MAP4K5 Homo sapiens Q9Y4K4
Pull Down
32707033
Intra MAP4K3 Q8IVH8 MAP4K5 Homo sapiens Q9Y4K4
Anti Tag CoIP
33961781
Cross MAP4K3 Q8IVH8 Prkcq Mus musculus Q02111
Anti Tag CoIP
21983831
Intra MAP4K3 Q8IVH8 LCP2 Homo sapiens Q13094
Anti Tag CoIP
21983831
Intra MAP4K3 Q8IVH8 LCP2 Homo sapiens Q13094
Anti Bait CoIP
21983831
Intra MAP4K3 Q8IVH8 PRKCQ Homo sapiens Q04759
Anti Tag CoIP
21983831
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.28% 否
HY-148065 FMF-06-098-1 / 否
HY-RS08077 MAP4K3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08078 Map4k3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08079 Map4k3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAP4K3 RGD RGD:621280
Felis catus MAP4K3 VGNC VGNC:81117
Mus musculus MAP4K3 MGD MGI:2154405
Macaca mulatta MAP4K3 VGNC VGNC:81466
Bos taurus MAP4K3 VGNC VGNC:31206
Canis familiaris MAP4K3 VGNC VGNC:42983
Others MAP4K3 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z