MAP4K5 - mitogen-activated protein kinase kinase kinase kinase 5 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶激酶 5

种属: Homo sapiens

同用名: KHS; GCKR; KHS1; MAPKKKK5

关于 MAP4K5

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶家族的成员，与酵母 SPS1/STE20 激酶高度相似。酵母 SPS1/STE20 在 MAP 激酶信号级联开始附近起作用，这对酵母信息素反应至关重要。这种激酶被证明可以激活哺乳动物细胞中的 Jun 激酶，这表明它在应激反应中起作用。已针对该基因描述了编码相同蛋白质的两个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]