Irs1 - insulin receptor substrate 1 Gene

种属: Rattus norvegicus

同用名: IRS1IRM

基因 ID: 25467 | 基因类型: protein coding

关于 Irs1

功能概要

Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of Insulin Receptor signaling pathway; and regulation of peptide hormone secretion. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Part of Insulin Receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; non-alcoholic fatty liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (Insulin Receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Irs1 基因产物(1)

mRNA	Protein	Name
NM_012969.2	NP_037101.2	insulin receptor substrate 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SH2 domain binding	IPI IPI: 通过物理相互作用推断	8491186	RGD
enables insulin receptor binding	IMP IMP: 通过突变表型推断	12850498	RGD
enables insulin-like growth factor receptor binding	IPI IPI: 通过物理相互作用推断	15272025	RGD
enables phosphatidylinositol 3-kinase binding	IDA IDA: 通过直接分析推断	1380456	RGD
enables phosphatidylinositol 3-kinase binding	IMP IMP: 通过突变表型推断	12850498	RGD
enables phosphatidylinositol 3-kinase binding	IPI IPI: 通过物理相互作用推断	12891559	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	1380456	RGD
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	12891559	RGD
enables protein kinase C binding	IPI IPI: 通过物理相互作用推断	18285345	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	15701573	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	15272025	RGD
enables transmembrane receptor protein tyrosine kinase adaptor activity	IMP IMP: 通过突变表型推断	18285345	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to angiotensin	IEP IEP: 通过表达模式推断	8579617	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: 通过表达模式推断	17467122	RGD
involved in cellular response to radiation	IEP IEP: 通过表达模式推断	17427956	RGD
involved in insulin receptor signaling pathway	IDA IDA: 通过直接分析推断	17925406	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	15069075	RGD
involved in negative regulation of insulin secretion	IMP IMP: 通过突变表型推断	12435589	RGD
involved in negative regulation of somatostatin secretion	IMP IMP: 通过突变表型推断	12435589	RGD
involved in positive regulation of glucagon secretion	IMP IMP: 通过突变表型推断	12435589	RGD
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	18285345	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	1380456	RGD
involved in positive regulation of phosphorylation	IDA IDA: 通过直接分析推断	12435589	RGD
involved in response to activity	IEP IEP: 通过表达模式推断	22015326	RGD
involved in response to caffeine	IDA IDA: 通过直接分析推断	21940847	RGD
involved in response to caffeine	IEP IEP: 通过表达模式推断	22995397	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of insulin receptor complex	IMP IMP: 通过突变表型推断	15069075	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

insulin receptor substrate 1

IRS-1

pp185

Irs1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Irs1	P35570	Phip	Mus musculus	Q8VDD9	Y2H	11018022
种属间	Irs1	P35570	TP53BP2	Homo sapiens	Q13625-2	Pull Down	17965023
种属间	Irs1	P35570	GRB2	Homo sapiens	P62993	Competition Binding	8491186
种属间	Irs1	P35570	GRB2	Homo sapiens	P62993	Pull Down	7504175
种属间	Irs1	P35570	GRB2	Homo sapiens	P62993	CoIP	8491186
种属间	Irs1	P35570	INSR	Homo sapiens	P06213	Phosphatase Assay	11136729
种属间	Irs1	P35570	INSR	Homo sapiens	P06213	Protein Kinase Assay	10660596
种属间	Irs1	P35570	INSR	Homo sapiens	P06213	Y2H	15629149
种属内	Irs1	P35570	Pik3r1	Rattus norvegicus	Q63787	CoIP	11136729
种属内	Irs1	P35570	Pik3r1	Rattus norvegicus	Q63787	CoIP	12446583
种属间	Irs1	P35570	Fyn	Mus musculus	P39688	Pull Down	8631859
种属间	Irs1	P35570	PIK3R1	Homo sapiens	P27986	Far-WB	10660596
种属内	Irs1	P35570	Pabpc1	Rattus norvegicus	Q9EPH8	Anti Bait CoIP	23770097
种属间	Irs1	P35570	PTPN1	Homo sapiens	P18031	Phosphatase Assay	10660596

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	Phase
HY-153479	Aganirsen	Inhibitor	/	Phase 3
HY-145935	NT219	Inhibitor	98.57%	Phase 2
HY-115461	MID-1	Inhibitor	99.36%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100037	NT157	Inhibitor	99.38%	否
HY-N0479	Licarin B	Activator	99.93%	否
HY-161321	PTP1B-IN-24		95.01%	否
HY-N3628	Coronarin A	Inhibitor	≥98.0%	否
HY-15113	Y-29794	Inhibitor	/	否
HY-15113A	Y-29794 tosylate	Inhibitor	/	否
HY-153479A	Aganirsen sodium	Inhibitor	/	否
HY-162499	MY17	Inhibitor	/	否
HY-N3542	Carpachromene	Inhibitor	/	否
HY-RS06917	IRS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-107758	Y-29794 oxalate	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Irs1	NCBI	NCBI:3667
Macaca fascicularis	Irs1	NCBI	NCBI:102117978
Mus musculus	Irs1	NCBI	NCBI:16367

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Irs1 - insulin receptor substrate 1 Gene

关于 Irs1

功能概要

Irs1 基因产物(1)

Irs1 蛋白互作信息

直系同源

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Irs1 - insulin receptor substrate 1 Gene

关于 Irs1

功能概要

Irs1 基因产物(1)

Irs1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z