2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. Phosphatase Insulin Receptor Akt
  4. PTP1B-IN-24

PTP1B-IN-24 (Compound 9) 是一种可逆的 PTP1B 抑制剂 IC50 值为 1.4 μM，并且可以提高 PTP1B 的热稳定性。PTP1B-IN-24 可通过提高 IRSI 和 AKT 的磷酸化水平来恢复 PA (HY-N0830) 诱导的胰岛素抵抗。

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PTP1B-IN-24 Chemical Structure

PTP1B-IN-24 Chemical Structure

CAS No. : 2221707-61-3

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规格 价格 是否有货
1 mg ￥1580
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5 mg ￥3150
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10 mg ￥5040
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25 mg 现货 询问价格 & 货期

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Customer Review

PTP1B-IN-24 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT[1].

IC50 & Target

Akt

1.4 μM (IC50)

体外研究
(In Vitro)

PTP1B-IN-24 (0-32 μM; 24 h) 在 LO2 细胞中不影响细胞活性。PTP1B-IN-24 (1-2 μM; 24 h) 在 HepG2 细胞中能改善 PA (0.4 mM; 24 h) 诱导的胰岛素抵抗[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PTP1B-IN-24 相关抗体:

Western Blot Analysis[1]

Cell Line: HepG2
Concentration: 1 μM; 2 μM
Incubation Time: 24 h
Result: Enhanced the phosphorylated expression of IRS1 (Y632) and Akt (S473).
分子量

420.44

Formula

C22H16N2O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PTP1B-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTP1B-IN-242221707-61-3PhosphataseInsulin ReceptorAktPKBProtein kinase BHepG2insulin resistanceLO2Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161321
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