Fyn - Fyn proto-oncogene Gene

种属: Mus musculus

基因 ID: 14360 | 基因类型: protein coding

关于 Fyn

功能概要

Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of protein targeting to membrane; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within several processes, including cellular response to growth factor stimulus; nervous system development; and protein phosphorylation. Located in several cellular components, including Schaffer collateral - CA1 synapse; actin filament; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human Fyn (Fyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fyn 基因产物(3)

mRNA	Protein	Name
NM_001122892.1	NP_001116364.1	tyrosine-protein kinase Fyn isoform b
NM_001122893.1	NP_001116365.1	tyrosine-protein kinase Fyn isoform a
NM_008054.2	NP_032080.2	tyrosine-protein kinase Fyn isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled receptor binding	IPI IPI: 通过物理相互作用推断	23169819	MGI
enables alpha-tubulin binding	IDA IDA: 通过直接分析推断	11826099	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	7730365	MGI
enables protein kinase activity	IDA IDA: 通过直接分析推断	11826099	MGI
enables protein tyrosine kinase activity	EXP EXP: 通过实验结果推断	16709819	MGI
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	8175795	MGI
enables protein tyrosine kinase activity	IGI IGI: 通过遗传相互作用推断	23169819	MGI
enables tau protein binding	IPI IPI: 通过物理相互作用推断	11826099	MGI
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	12538589	MGI
enables tubulin binding	IDA IDA: 通过直接分析推断	11826099	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within activated T cell proliferation	IMP IMP: 通过突变表型推断	1516132	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	9177270	MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus	IDA IDA: 通过直接分析推断	17623777	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IGI IGI: 通过遗传相互作用推断	21829547	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: 通过突变表型推断	12372285	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: 通过突变表型推断	16190898	MGI
acts upstream of or within forebrain development	IGI IGI: 通过遗传相互作用推断	16162939	MGI
acts upstream of or within forebrain development	IMP IMP: 通过突变表型推断	15073522	MGI
acts upstream of or within gene expression	IGI IGI: 通过遗传相互作用推断	31461442	MGI
involved in heart process	IGI IGI: 通过遗传相互作用推断	27525436	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	1361685	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: 通过突变表型推断	1361685	MGI
involved in negative regulation of angiogenesis	IMP IMP: 通过突变表型推断	10613822	MGI
involved in negative regulation of dendritic spine maintenance	IGI IGI: 通过遗传相互作用推断	22820466	MGI
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	20978343	MGI
acts upstream of or within negative regulation of protein catabolic process	IMP IMP: 通过突变表型推断	16841086	MGI
acts upstream of or within negative regulation of protein ubiquitination	IDA IDA: 通过直接分析推断	24627473	MGI
acts upstream of or within neuron migration	IGI IGI: 通过遗传相互作用推断	16162939	MGI
acts upstream of or within neuron migration	IMP IMP: 通过突变表型推断	15073522	MGI
acts upstream of neuron projection development	IGI IGI: 通过遗传相互作用推断	18354028	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	8175795	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	12681493	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IMP IMP: 通过突变表型推断	9381182	MGI
involved in peptidyl-tyrosine phosphorylation	IMP IMP: 通过突变表型推断	27525436	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: 通过遗传相互作用推断	18354028	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IDA IDA: 通过直接分析推断	20142099	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: 通过突变表型推断	20142099	MGI
involved in positive regulation of protein targeting to membrane	IGI IGI: 通过遗传相互作用推断	22820466	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	23438599	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: 通过直接分析推断	8175795	MGI
acts upstream of protein catabolic process	IMP IMP: 通过突变表型推断	16841086	MGI
acts upstream of or within protein phosphorylation	IMP IMP: 通过突变表型推断	9892651	MGI
acts upstream of protein ubiquitination	IDA IDA: 通过直接分析推断	24627473	MGI
involved in reelin-mediated signaling pathway	IDA IDA: 通过直接分析推断	12526739	MGI
involved in regulation of calcium ion import across plasma membrane	IGI IGI: 通过遗传相互作用推断	22820466	MGI
acts upstream of or within regulation of cell shape	IDA IDA: 通过直接分析推断	11826099	MGI
involved in regulation of glutamate receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	22820466	MGI
involved in regulation of peptidyl-tyrosine phosphorylation	IGI IGI: 通过遗传相互作用推断	22820466	MGI
involved in response to amyloid-beta	IGI IGI: 通过遗传相互作用推断	22820466	MGI
acts upstream of or within response to ethanol	IGI IGI: 通过遗传相互作用推断	9381182	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in Schaffer collateral - CA1 synapse	IDA IDA: 通过直接分析推断	1361685	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: 通过突变表型推断	1361685	MGI
located in actin filament	IDA IDA: 通过直接分析推断	17623777	MGI
located in cell body	IDA IDA: 通过直接分析推断	11826099	MGI
located in cell periphery	IDA IDA: 通过直接分析推断	17623777	MGI
located in dendrite	IMP IMP: 通过突变表型推断	20655099	MGI
located in endosome	IDA IDA: 通过直接分析推断	17623777	MGI
located in glial cell projection	IDA IDA: 通过直接分析推断	11826099	MGI
located in membrane raft	IDA IDA: 通过直接分析推断	11826099	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	10557075	MGI
located in postsynaptic density	IMP IMP: 通过突变表型推断	20655099	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

tyrosine-protein kinase Fyn

Src Kinase p59	p59-Fyn
proto-oncogene c-Fyn	proto-oncogene tyrosine-protein kinase Fyn

Fyn 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Fyn	P39688	Pdgfrb	Mus musculus	P05622	Pull Down	7730365
种属间	Fyn	P39688	CBL	Homo sapiens	P22681	Pull Down	9890970
种属间	Fyn	P39688	CBL	Homo sapiens	P22681	Far-WB	9890970
种属内	Fyn	P39688	Khdrbs1	Mus musculus	Q60749	Y2H	15102471
种属间	Fyn	P39688	FZD2	Homo sapiens	Q14332	Pull Down	25417160
种属内	Fyn	P39688	Dynlt1	Mus musculus	P51807	Y2H	15102471
种属内	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Anti Bait CoIP	12545173
种属内	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Anti Tag CoIP	12545173
种属内	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Pull Down	16847311
种属内	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Anti Bait CoIP	11477403
种属内	Fyn	P39688	Khdrbs2	Mus musculus	Q9WU01	Pull Down	10077576
种属内	Fyn	P39688	Sphk2	Mus musculus	Q9JIA7	Anti Bait CoIP	16316995
种属间	Fyn	P39688	Irs1	Rattus norvegicus	P35570	Pull Down	8631859
种属间	Fyn	P39688	Irs1	Rattus norvegicus	P35570	Anti Bait CoIP	8631859

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-118105	RK-20448	Inhibitor	99.38%	否
HY-120622	BMS-243117	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Fyn	NCBI	NCBI:2534

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