2. Protein Tyrosine Kinase/RTK
  3. Src
  4. BMS-243117

BMS-243117 是一种强效、选择性苯并噻唑类 p56Lck 抑制剂，IC50 为 4 nM。BMS-243117 可抑制 anti-CD3/anti-CD28 诱导的 PBL (人类外周血 T 细胞) 增殖，IC50 为 1.1 μM。BMS-243117 以延伸构象与 Lck 的 ATP 结合位点结合。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BMS-243117 Chemical Structure

BMS-243117 Chemical Structure

CAS No. : 225521-80-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

BMS-243117 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

查看所有亚型
Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMS-243117 is a potent, and selective benzothiazole based p56Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck[1].

IC50 & Target[1]

Lck

4 nM (IC50)

Fyn

32 nM (IC50)

Blk

84 nM (IC50)

Src

158 nM (IC50)

Hck

960 nM (IC50)

Lyn

330 nM (IC50)

Fgr

60 nM (IC50)

分子量

416.92

Formula

C20H21ClN4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMS-243117 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-243117225521-80-2BMS243117BMS 243117SrcBenzothiazoleanti-CD3anti-CD28PBL proliferationATP-binding siteInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
BMS-243117
目录号：
HY-120622
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z