Pik3r1 - phosphoinositide-3-kinase regulatory subunit 1 Gene

种属: Rattus norvegicus

同用名: PI3KA

基因 ID: 25513 | 基因类型: protein coding

关于 Pik3r1

功能概要

Enables several functions, including 1-phosphatidylinositol-3-kinase regulator activity; Calmodulin binding activity; and Enzyme binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including regulation of phosphorylation; response to steroid hormone; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in neuron projection; nucleus; and plasma membrane. Part of phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial Cancer (multiple); immunodeficiency 36; and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pik3r1 基因产物(1)

mRNA	Protein	Name
NM_013005.2	NP_037137.2	phosphatidylinositol 3-kinase regulatory subunit alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to 1-phosphatidylinositol-3-kinase activity	IDA IDA: 通过直接分析推断	20236230	RGD
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA IDA: 通过直接分析推断	12882977	RGD
enables ATPase binding	IPI IPI: 通过物理相互作用推断	17728397	RGD
enables calmodulin binding	IPI IPI: 通过物理相互作用推断	17492691	RGD
enables insulin receptor substrate binding	IPI IPI: 通过物理相互作用推断	12891559	RGD
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	16971528	RGD
enables phosphoprotein binding	IPI IPI: 通过物理相互作用推断	12882964	RGD
enables platelet-derived growth factor receptor binding	IPI IPI: 通过物理相互作用推断	18421086	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	10437794	RGD
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	10973965	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	15530849	RGD
enables receptor tyrosine kinase binding	IPI IPI: 通过物理相互作用推断	18292389	RGD
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	14962484	RGD
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	18773943	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to fatty acid	IEP IEP: 通过表达模式推断	17593346	RGD
involved in cellular response to insulin stimulus	IEP IEP: 通过表达模式推断	18922131	RGD
involved in glucose metabolic process	IMP IMP: 通过突变表型推断	9440811	RGD
involved in insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	15161606	RGD
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	9440811	RGD
involved in negative regulation of blood pressure	IMP IMP: 通过突变表型推断	19015400	RGD
involved in negative regulation of cell-cell adhesion	IMP IMP: 通过突变表型推断	15530849	RGD
involved in negative regulation of heart rate	IMP IMP: 通过突变表型推断	19015400	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: 通过突变表型推断	15089039	RGD
involved in negative regulation of proteolysis	IMP IMP: 通过突变表型推断	15161606	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	19783773	RGD
involved in phosphatidylinositol metabolic process	IDA IDA: 通过直接分析推断	12882977	RGD
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	15530849	RGD
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	20333648	RGD
involved in positive regulation of myoblast differentiation	IMP IMP: 通过突变表型推断	9440811	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	19723872	RGD
involved in positive regulation of synapse assembly	IDA IDA: 通过直接分析推断	21414895	RGD
involved in response to amino acid	IEP IEP: 通过表达模式推断	19106217	RGD
involved in response to cAMP	IDA IDA: 通过直接分析推断	10875243	RGD
involved in response to dexamethasone	IEP IEP: 通过表达模式推断	20032058	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	19462258	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	17622585	RGD
involved in response to fatty acid	IEP IEP: 通过表达模式推断	19369057	RGD
involved in response to fructose	IEP IEP: 通过表达模式推断	17976658	RGD
involved in response to glucocorticoid	IDA IDA: 通过直接分析推断	15187100	RGD
involved in response to growth factor	IEP IEP: 通过表达模式推断	18421086	RGD
involved in response to insulin	IDA IDA: 通过直接分析推断	16150536	RGD
involved in response to iron(II) ion	IEP IEP: 通过表达模式推断	17600839	RGD
involved in response to nutrient	IEP IEP: 通过表达模式推断	19657097	RGD
involved in response to progesterone	IEP IEP: 通过表达模式推断	18752305	RGD
involved in response to testosterone	IEP IEP: 通过表达模式推断	20032058	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	20519555	RGD
involved in response to yeast	IEP IEP: 通过表达模式推断	19958054	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of phosphatidylinositol 3-kinase complex	IDA IDA: 通过直接分析推断	12882977	RGD
part of protein-containing complex	IDA IDA: 通过直接分析推断	10973965	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

phosphatidylinositol 3-kinase regulatory subunit alpha

PI3-kinase p85 subunit alpha	PI3-kinase regulatory subunit alpha
PI3-kinase subunit p85-alpha	PI3K regulatory subunit alpha
Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50)	Phosphoinositide 3-kinase, regulatory subunit, polypeptid

Pik3r1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	Pik3r1	Q63787	Shtn1	Rattus norvegicus	A0MZ67	Anti Bait CoIP	17030985
Cross	Pik3r1	Q63787	PDE6G	Homo sapiens	P18545	Y2H	16357825
Intra	Pik3r1	Q63787	Khdrbs1	Rattus norvegicus	Q91V33	CoIP	10437794
Intra	Pik3r1	Q63787	Gabra1	Rattus norvegicus	P62813	Filter Binding	16890252
Intra	Pik3r1	Q63787	Gabra1	Rattus norvegicus	P62813	Anti Bait CoIP	16890252
Intra	Pik3r1	Q63787	Gabra1	Rattus norvegicus	P62813	Pull Down	16890252

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-161366	OMS14	Inhibitor	99.09%	否
HY-RS10536	PIK3R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Pik3r1	NCBI	NCBI:5295

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Pik3r1 - phosphoinositide-3-kinase regulatory subunit 1 Gene

关于 Pik3r1

功能概要

Pik3r1 基因产物(1)

Pik3r1 蛋白互作信息

直系同源

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Pik3r1 - phosphoinositide-3-kinase regulatory subunit 1 Gene

关于 Pik3r1

功能概要

Pik3r1 基因产物(1)

Pik3r1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z