PARD6A - par-6 family cell polarity regulator alpha Gene

中文名称：par-6 系列电池极性调节器 alpha

种属: Homo sapiens

同用名: PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

关于 PARD6A

功能概要

该基因是 PAR6 家族的成员，编码具有 PSD95/Discs-large/ZO1 (PDZ) 结构域和半 Cdc42/Rac 交互结合 (CRIB) 结构域的蛋白质。这种细胞膜蛋白作为多蛋白复合物的成员参与不对称细胞分裂和细胞极化过程。该蛋白还在上皮-间充质转化 (EMT) 中发挥作用，EMT 表征与转移癌相关的侵袭性表型。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]