PARD3 - par-3 family cell polarity regulator Gene

中文名称：par-3 系列电池极性调节器

种属: Homo sapiens

同用名: Baz; ASIP; PAR3; PARD-3; PARD3A; SE2-5T2; PPP1R118; SE2-5L16; SE2-5LT1; PAR3alpha

基因 ID: 56288 | 基因类型: protein coding

关于 PARD3

Cytogenetic location: 10p11.22-p11.21 Genomic coordinates (GRCh38): 10:34,109,561-34,815,296 (from NCBI)

This gene has 16 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 6.9), skin (RPKM 6.8) and 24 other tissues.

功能概要

该基因编码 PARD 蛋白家族的一个成员。 PARD 家族成员与其他 PARD 家族成员和其他蛋白质相互作用；它们影响不对称细胞分裂和直接极化细胞生长。已针对该基因描述了多个选择性剪接的转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the PARD protein family. PARD family members interact with Other PARD family members and Other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

PARD3 基因产物(11)

mRNA	Protein	Name
NM_001184785.2	NP_001171714.1	partitioning defective 3 homolog isoform 2
NM_001184786.2	NP_001171715.1	partitioning defective 3 homolog isoform 3
NM_001184787.2	NP_001171716.1	partitioning defective 3 homolog isoform 4
NM_001184788.2	NP_001171717.1	partitioning defective 3 homolog isoform 5
NM_001184789.2	NP_001171718.1	partitioning defective 3 homolog isoform 6
NM_001184790.2	NP_001171719.1	partitioning defective 3 homolog isoform 7
NM_001184791.2	NP_001171720.1	partitioning defective 3 homolog isoform 8
NM_001184792.2	NP_001171721.1	partitioning defective 3 homolog isoform 9
NM_001184793.2	NP_001171722.1	partitioning defective 3 homolog isoform 10
NM_001184794.2	NP_001171723.1	partitioning defective 3 homolog isoform 11
NM_019619.4	NP_062565.2	partitioning defective 3 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10934474	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: 通过直接分析推断	11257119	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PAR polarity complex	IPI IPI: 通过物理相互作用推断	11257119	GOA
located in bicellular tight junction	IDA IDA: 通过直接分析推断	14676191	GOA
located in cell-cell junction	IDA IDA: 通过直接分析推断	20332120	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARD3 蛋白结构

DUF3534

PDZ

0
300
600
900
1200
1356 a.a.

蛋白主名

其他名称

partitioning defective 3 homolog

CTCL tumor antigen se2-5

PARD3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PARD3	Q8TEW0	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
种属内	PARD3	Q8TEW0	CDH5	Homo sapiens	P33151	Imaging	17057644
种属内	PARD3	Q8TEW0	CDH5	Homo sapiens	P33151	Pull Down	17057644
种属内	PARD3	Q8TEW0	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	14676191
种属内	PARD3	Q8TEW0	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
种属内	PARD3	Q8TEW0	PNMA1	Homo sapiens	Q8ND90	Anti Tag CoIP	14676191
种属内	PARD3	Q8TEW0	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
种属内	PARD3	Q8TEW0	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	PARD3	Q8TEW0	F11R	Homo sapiens	Q9Y624	Pull Down	17057644
种属间	PARD3	Q8TEW0	Tiam2	Mus musculus	Q6ZPF3	Pull Down	19893486
种属间	PARD3	Q8TEW0	Tiam2	Mus musculus	Q6ZPF3	SPR	19893486
种属内	PARD3	Q8TEW0	PARD6A	Homo sapiens	Q9NPB6	Anti Bait CoIP	17057644
种属内	PARD3	Q8TEW0	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	14676191
种属内	PARD3	Q8TEW0	PARD6A	Homo sapiens	Q9NPB6	CoIP	11257119
种属间	PARD3	Q8TEW0	Prkci	Mus musculus	Q62074	Protein Kinase Assay	22579248
种属间	PARD3	Q8TEW0	Prkci	Mus musculus	Q62074	Pull Down	22579248

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Myelomeningocele

Meningomyelocele

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10037	PARD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PARD3	VGNC	VGNC:44263
Rattus norvegicus	PARD3	RGD	RGD:620374
Mus musculus	PARD3	MGD	MGI:2135608
Felis catus	PARD3	VGNC	VGNC:64040
Bos taurus	PARD3	VGNC	VGNC:32582
Macaca mulatta	PARD3	VGNC	VGNC:75618

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PARD3 - par-3 family cell polarity regulator Gene

关于 PARD3

功能概要

PARD3 基因产物(11)

PARD3 蛋白结构

PARD3 蛋白互作信息

关联疾病

直系同源

热门区域

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PARD3 - par-3 family cell polarity regulator Gene

关于 PARD3

功能概要

PARD3 基因产物(11)

PARD3 蛋白结构

PARD3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z