Prkci - protein kinase C, iota Gene

中文名称：蛋白激酶 C，iota

种属: Mus musculus

同用名: Pkci; Pkcl; Prkcl; PKClambda; mKIAA4165; aPKClambda; 2310021H13Rik

关于 Prkci

功能概要

该基因编码的蛋白可启动蛋白激酶 C 活性。参与多个过程，包括细胞对胰岛素刺激的反应；积极调节葡萄糖输入；和蛋白质定位到质膜的正调节。作用于肌动蛋白丝组织的上游或内部；建立顶端/基底细胞极性；和眼睛感光细胞的发育。位于多个细胞成分中，包括 Schmidt-Lanterman 切迹；顶端质膜；和核。以多种结构表达，包括消化系统；脑;泌尿生殖系统；肺;和感觉器官。用于研究腹型肥胖-代谢综合征；肥胖;和 2 型糖尿病。与人 PRKCI（蛋白激酶 C iota）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase C activity. Involved in several processes, including cellular response to Insulin stimulus; positive regulation of glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Apr 2022]