PRKCI - protein kinase C iota Gene

中文名称：蛋白激酶 Ciota

种属: Homo sapiens

同用名: PKCI; DXS1179E; nPKC-iota

基因 ID: 5584 | 基因类型: protein coding

关于 PRKCI

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,222,424-170,305,977 (from NCBI)

This gene has 7 transcripts (splice variants), 226 orthologues and 9 paralogues. Ubiquitous expression in stomach (RPKM 19.1), thyroid (RPKM 17.9) and 24 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶蛋白激酶 C (PKC) 家族的成员。 PKC 家族至少包含 8 个成员，它们表达差异，参与多种细胞过程。这种蛋白激酶是钙非依赖性和磷脂依赖性的。它不会被佛波酯或甘油二酯激活。这种激酶可以通过与小 GTPase RAB2 的直接相互作用被募集到囊泡管状簇 (VTC) ，其中这种激酶磷酸化甘油醛-3-磷酸脱氢酶 (GAPD/GAPDH) ，并在早期分泌途径的微管动力学中发挥作用。发现该激酶对于 BCL-ABL 介导的对药物诱导的细胞凋亡的抗性是必需的，因此保护白血病细胞免受药物诱导的细胞凋亡。 X 染色体上有一个外显子假基因。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced Apoptosis and therefore protects leukemia cells against drug-induced Apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]

PRKCI 基因产物(3)

mRNA	Protein	Name
NM_002740.6	NP_002731.4	protein kinase C iota type
XM_047448574.1	XP_047304530.1	protein kinase C iota type isoform X1
XM_047448575.1	XP_047304531.1	protein kinase C iota type isoform X2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: 通过实验结果推断	12700136	GOA
enables phospholipid binding	IDA IDA: 通过直接分析推断	8226978	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11257119	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	11724794	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	8226978	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell-cell junction organization	IMP IMP: 通过突变表型推断	11257119	GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: 通过直接分析推断	11257119	GOA
involved in negative regulation of glial cell apoptotic process	IMP IMP: 通过突变表型推断	21419810	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: 通过直接分析推断	10467349	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	10467349	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: 通过突变表型推断	19327373	GOA
involved in positive regulation of glial cell proliferation	IMP IMP: 通过突变表型推断	21419810	GOA
involved in positive regulation of neuron projection development	IDA IDA: 通过直接分析推断	36250347	GOA
involved in positive regulation of neuron projection development	IMP IMP: 通过突变表型推断	10467349	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	8226978	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PAR polarity complex	IPI IPI: 通过物理相互作用推断	11257119	GOA
located in cytosol	IDA IDA: 通过直接分析推断	11257119	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11260256	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCI 蛋白结构

PB1

C1_1

Pkinase

Pkinase_C

0
100
200
300
400
500
596 a.a.

蛋白主名

其他名称

protein kinase C iota type

PRKC-lambda/iota	aPKC-lambda/iota
atypical protein kinase C-lambda/iota

PRKCI 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRKCI	P41743	ELF3	Homo sapiens	P78545	Anti Bait CoIP	26977885
种属内	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6-2	Validated Y2H	32296183
种属内	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	PRKCI	P41743	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	PRKCI	P41743	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	31980649
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	25416956
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Pull Down	11260256
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	26496610
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	35271311
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	31980649
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Anti Tag CoIP	14676191
种属内	PRKCI	P41743	PARD6B	Homo sapiens	Q9BYG5	Y2H	11260256
种属内	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	31980649
种属内	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Y2H	11260256
种属内	PRKCI	P41743	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
种属内	PRKCI	P41743	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
种属内	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	31980649
种属内	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32296183
种属内	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
种属内	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20808283
种属内	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Y2H Prey Pooling	32296183
种属内	PRKCI	P41743	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	14676191
种属内	PRKCI	P41743	RAC1	Homo sapiens	P63000	Pull Down	11260256
种属内	PRKCI	P41743	SOX2	Homo sapiens	P48431	Protein Kinase Assay	24525231
种属内	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
种属内	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
种属内	PRKCI	P41743	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
种属内	PRKCI	P41743	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
种属内	PRKCI	P41743	CDC42	Homo sapiens	P60953	Pull Down	11260256
种属内	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Anti Tag CoIP	14676191
种属内	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Array	25416956
种属内	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Pooling	16189514
种属内	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H	11260256
种属内	PRKCI	P41743	PARD6A	Homo sapiens	Q9NPB6	Y2H Prey Pooling	25416956
种属内	PRKCI	P41743	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	31980649
种属内	PRKCI	P41743	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	14676191

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRKCI 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74630	PKC iota Protein, Human (sf9, GST)	P41743 (M10-V596)	≥95%

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11134	PRKCI Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11135	Prkci Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS11136	Prkci Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PRKCI	VGNC	VGNC:69062
Mus musculus	PRKCI	MGD	MGI:99260
Bos taurus	PRKCI	VGNC	VGNC:33333
Canis familiaris	PRKCI	VGNC	VGNC:44982
Rattus norvegicus	PRKCI	RGD	RGD:620961
Macaca mulatta	PRKCI	VGNC	VGNC:84064
Others	PRKCI	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4