CDCA4 - cell division cycle associated 4 Gene

中文名称：细胞分裂周期相关 4

种属: Homo sapiens

同用名: HEPP; SEI-3/HEPP

关于 CDCA4

功能概要

该基因编码一种属于 E2F 转录因子家族的蛋白质。该蛋白主要通过 E2F/视网膜母细胞瘤蛋白通路调节 E2F 依赖性转录激活和细胞增殖。它还在 JUN 致癌基因表达的调节中发挥作用。这种蛋白质显示出独特的核有丝分裂器分布，它参与了前中期的纺锤体组织，并且还可能作为参与染色体分离或胞质分裂的中间区因子发挥作用。已经注意到该基因有两个编码相同蛋白质的可变剪接转录物变体。还在 1 号染色体上鉴定出两个假基因。[RefSeq 提供，2014 年 5 月]

This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]