SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

中文名称：SUV39H2 组蛋白赖氨酸甲基转移酶

种属: Homo sapiens

同用名: KMT1B

基因 ID: 79723 | 基因类型: protein coding

关于 SUV39H2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:14,878,866-14,904,315 (from NCBI)

This gene has 8 transcripts (splice variants), 145 orthologues and 19 paralogues. Broad expression in testis (RPKM 10.3), lymph node (RPKM 2.1) and 23 other tissues.

功能概要

启用 S-腺苷-L-甲硫氨酸结合活性；组蛋白甲基转移酶活性 (H3-K9 特异性) ；和锌离子结合活性。参与染色质组装或拆卸以及染色质重塑。在细胞对缺氧和 RNA 聚合酶 II 的转录负调节反应的上游或细胞内起作用。位于染色质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables S-adenosyl-L-methionine binding activity; Histone Methyltransferase activity (H3-K9 specific); and zinc ion binding activity. Involved in chromatin assembly or disassembly and chromatin remodeling. Acts upstream of or within cellular response to hypoxia and negative regulation of transcription by RNA polymerase II. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SUV39H2 基因产物(5)

mRNA	Protein	Name
NM_001193424.2	NP_001180353.1	histone-lysine N-methyltransferase SUV39H2 isoform 1
NM_001193425.2	NP_001180354.1	histone-lysine N-methyltransferase SUV39H2 isoform 2
NM_001193426.2	NP_001180355.1	histone-lysine N-methyltransferase SUV39H2 isoform 3
NM_001193427.2	NP_001180356.1	histone-lysine N-methyltransferase SUV39H2 isoform 4
NM_024670.4	NP_078946.1	histone-lysine N-methyltransferase SUV39H2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables S-adenosyl-L-methionine binding	IDA IDA: 通过直接分析推断	20084102	GOA
enables histone H3K9 methyltransferase activity	IDA IDA: 通过直接分析推断	10949293	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: 通过直接分析推断	30111536	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	20084102	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within cellular response to hypoxia	IDA IDA: 通过直接分析推断	21402781	GOA
involved in chromatin organization	IMP IMP: 通过突变表型推断	10949293	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	10949293	GOA
involved in epigenetic programming in the zygotic pronuclei	IDA IDA: 通过直接分析推断	30111536	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21402781	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	10949293	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	30111536	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUV39H2 蛋白结构

Chromo

Pre-SET

SET

0
100
200
300
410 a.a.

蛋白主名

其他名称

histone-lysine N-methyltransferase SUV39H2

H3-K9-HMTase 2

SUV39H2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SUV39H2	Q9H5I1	HEL25	Homo sapiens	V9HWG0	Y2H Array	25416956
种属内	SUV39H2	Q9H5I1	PHF19	Homo sapiens	Q5T6S3	Anti Tag CoIP	23455924
种属内	SUV39H2	Q9H5I1	PHF19	Homo sapiens	Q5T6S3	Y2H	23455924
种属内	SUV39H2	Q9H5I1	PNMA1	Homo sapiens	Q8ND90	MAPPIT	25416956
种属内	SUV39H2	Q9H5I1	NCK1	Homo sapiens	P16333	Peptide Array	17474147
种属内	SUV39H2	Q9H5I1	APPL2	Homo sapiens	Q8NEU8	Y2H Array	31515488
种属内	SUV39H2	Q9H5I1	APPL2	Homo sapiens	Q8NEU8	Validated Y2H	25416956
种属内	SUV39H2	Q9H5I1	APPL2	Homo sapiens	Q8NEU8	Y2H Array	25416956
种属内	SUV39H2	Q9H5I1	KCTD17	Homo sapiens	Q8N5Z5	Y2H	23455924
种属内	SUV39H2	Q9H5I1	KCTD17	Homo sapiens	Q8N5Z5	Anti Tag CoIP	23455924
种属内	SUV39H2	Q9H5I1	KLHDC4	Homo sapiens	Q8TBB5	Anti Tag CoIP	23455924
种属内	SUV39H2	Q9H5I1	KLHDC4	Homo sapiens	Q8TBB5	Y2H	23455924
种属内	SUV39H2	Q9H5I1	MRFAP1	Homo sapiens	Q9Y605	Y2H	23455924

种属间: 跨种属相互作用 种属内: 同种属相互作用

SUV39H2 抗体

目录号	产品名	应用	反应物种
HY-P82137	KMT1B Antibody (YA1882)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-122181B	OTS186935 hydrochloride	Inhibitor	99.22%	否
HY-13807	UNC0646	Inhibitor	99.38%	否
HY-122181	OTS186935	Inhibitor	98.55%	否
HY-122182	OTS193320		98.64%	否
HY-148817	WDR5-0102	Inhibitor	97.02%	否
HY-122181A	OTS186935 trihydrochloride	Inhibitor	/	否
HY-RS14052	SUV39H2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SUV39H2	VGNC	VGNC:35492
Macaca mulatta	SUV39H2	VGNC	VGNC:103876
Rattus norvegicus	SUV39H2	RGD	RGD:1306969
Felis catus	SUV39H2	VGNC	VGNC:65858
Canis familiaris	SUV39H2	VGNC	VGNC:84435
Mus musculus	SUV39H2	MGD	MGI:1890396

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

关于 SUV39H2

功能概要

SUV39H2 基因产物(5)

SUV39H2 蛋白结构

SUV39H2 蛋白互作信息

SUV39H2 抗体

关联疾病

直系同源

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SUV39H2 - SUV39H2 histone lysine methyltransferase Gene

关于 SUV39H2

功能概要

SUV39H2 基因产物(5)

SUV39H2 蛋白结构

SUV39H2 蛋白互作信息

SUV39H2 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z