2. Gene
  3. PHF19 - PHD finger protein 19 Gene

PHF19 - PHD finger protein 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PHD 指蛋白 19

种属: Homo sapiens

同用名: PCL3; MTF2L1; TDRD19B

基因 ID: 26147 | 基因类型: protein coding

关于 PHF19

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,855,651-120,904,128 (from NCBI)

This gene has 14 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 8.7), ovary (RPKM 6.6) and 24 other tissues.

功能概要

启用甲基化组蛋白结合活性。参与组蛋白 H3-K27 甲基化的正调控。与 ESC/E (Z) 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables methylated histone binding activity. Involved in positive regulation of histone H3-K27 methylation. Colocalizes with ESC/E(Z) complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF19 基因产物(5)

mRNA Protein Name
NM_001009936.3 NP_001009936.1 PHD finger protein 19 isoform b
NM_001286840.1 NP_001273769.1 PHD finger protein 19 isoform c
NM_001286842.1 NP_001273771.1 PHD finger protein 19 isoform d
NM_001286843.2 NP_001273772.1 PHD finger protein 19 isoform e
NM_015651.3 NP_056466.1 PHD finger protein 19 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylated histone binding IDA
IDA: 通过直接分析推断
23104054 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23104054 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
23104054 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESC/E(Z) complex IDA
IDA: 通过直接分析推断
23104054 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHF19 蛋白结构

PHD

PHD: PHD-finger (99 - 149)

Mtf2_C

Mtf2_C: Polycomb-like MTF2 factor 2 (530 - 578)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
蛋白主名 其他名称

PHD finger protein 19

polycomb like 3

PHF19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PHF19 Q5T6S3 ZNF837 Homo sapiens Q96EG3
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra PHF19 Q5T6S3 ZNF837 Homo sapiens Q96EG3
Y2H Array
32296183
Intra PHF19 Q5T6S3 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra PHF19 Q5T6S3 POTEB3 Homo sapiens A0JP26
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 POTEB3 Homo sapiens A0JP26
Y2H Array
32296183
Intra PHF19 Q5T6S3 YTHDC1 Homo sapiens Q96MU7
Validated Y2H
32296183
Intra PHF19 Q5T6S3 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra PHF19 Q5T6S3 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 SUV39H1 Homo sapiens O43463
Y2H
23455924
Intra PHF19 Q5T6S3 SUV39H1 Homo sapiens O43463
Anti Tag CoIP
23455924
Intra PHF19 Q5T6S3 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra PHF19 Q5T6S3 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra PHF19 Q5T6S3 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra PHF19 Q5T6S3 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra PHF19 Q5T6S3 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra PHF19 Q5T6S3 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra PHF19 Q5T6S3 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra PHF19 Q5T6S3 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra PHF19 Q5T6S3 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra PHF19 Q5T6S3 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra PHF19 Q5T6S3 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra PHF19 Q5T6S3 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra PHF19 Q5T6S3 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra PHF19 Q5T6S3 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra PHF19 Q5T6S3 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra PHF19 Q5T6S3 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Intra PHF19 Q5T6S3 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra PHF19 Q5T6S3 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra PHF19 Q5T6S3 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra PHF19 Q5T6S3 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra PHF19 Q5T6S3 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra PHF19 Q5T6S3 SNIP1 Homo sapiens Q8TAD8
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 SNIP1 Homo sapiens Q8TAD8
Validated Y2H
32296183
Intra PHF19 Q5T6S3 SNIP1 Homo sapiens Q8TAD8
Y2H Array
32296183
Intra PHF19 Q5T6S3 INO80E Homo sapiens Q8NBZ0
Y2H Array
32296183
Intra PHF19 Q5T6S3 INO80E Homo sapiens Q8NBZ0
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 INO80E Homo sapiens Q8NBZ0
Validated Y2H
32296183
Intra PHF19 Q5T6S3 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra PHF19 Q5T6S3 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra PHF19 Q5T6S3 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra PHF19 Q5T6S3 TSPYL2 Homo sapiens Q9H2G4
Y2H Array
32296183
Intra PHF19 Q5T6S3 TSPYL2 Homo sapiens Q9H2G4
Validated Y2H
32296183
Intra PHF19 Q5T6S3 TSPYL2 Homo sapiens Q9H2G4
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10419 PHF19 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PHF19 VGNC VGNC:64140
Bos taurus PHF19 VGNC VGNC:32817
Mus musculus PHF19 MGD MGI:1921266
Macaca mulatta PHF19 VGNC VGNC:75857
Canis familiaris PHF19 VGNC VGNC:59040
Rattus norvegicus PHF19 RGD RGD:1310390
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