2. Gene
  3. TSPYL2 - TSPY like 2 Gene

TSPYL2 - TSPY like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：样 2

种属: Homo sapiens

同用名: CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216

基因 ID: 64061 | 基因类型: protein coding

关于 TSPYL2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:53,082,367-53,088,540 (from NCBI)

This gene has 6 transcripts (splice variants), 224 orthologues and 18 paralogues. Broad expression in ovary (RPKM 45.2), testis (RPKM 42.8) and 24 other tissues.

功能概要

该基因编码睾丸特异性蛋白 Y 编码、TSPY 样/SET/核小体组装蛋白 1 超家族的成员。编码的蛋白质定位于核仁，在那里它在染色质重塑中发挥作用，并作为细胞周期进程的抑制剂。这种蛋白质可能在抑制肿瘤生长方面发挥作用。[RefSeq 提供，2009 年 9 月]

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

TSPYL2 基因产物(1)

mRNA Protein Name
NM_022117.4 NP_071400.1 testis-specific Y-encoded-like protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26496610 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA replication IDA
IDA: 通过直接分析推断
11395479 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
11395479 GOA
involved in regulation of protein kinase activity IDA
IDA: 通过直接分析推断
11395479 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
11395479 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11395479 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSPYL2 蛋白结构

NAP

NAP: Nucleosome assembly protein (NAP) (216 - 398)

  • 0
  • 200
  • 400
  • 600
  • 693 a.a.
蛋白主名 其他名称

testis-specific Y-encoded-like protein 2

CASK-interacting nucleosome assembly protein

TSPYL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TSPYL2 Q9H2G4 ZNF286A Homo sapiens Q9HBT8
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 ZNF687 Homo sapiens Q8N1G0
Y2H Prey Pooling
32296183
Intra TSPYL2 Q9H2G4 ZNF687 Homo sapiens Q8N1G0
Y2H Array
32296183
Intra TSPYL2 Q9H2G4 H2BC15 Homo sapiens U3KQK0
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 XAGE1A Homo sapiens Q9HD64
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 ABT1 Homo sapiens Q9ULW3
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 NOL12 Homo sapiens Q9UGY1
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 NOP53 Homo sapiens Q9NZM5
Validated Y2H
32296183
Intra TSPYL2 Q9H2G4 HMGXB4 Homo sapiens Q9UGU5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gonadoblastoma

GBY
Pitt-Hopkins-Like Syndrome 2

PTHSL2

Mesh

D006985

Mesh

D008607
Syndromic X-Linked Intellectual Disability Najm Type

Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia

Micpch

X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome
Syndromic X-Linked Intellectual Disability Claes-Jensen Type

Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type

Mrxscj

Mrxsj

Syndromic X-Linked Intellectual Disability Due To Jarid1c Mutation

Syndromic X-Linked Mental Retardation Jarid1c-Related
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15182 TSPYL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TSPYL2 VGNC VGNC:66640
Mus musculus TSPYL2 MGD MGI:106244
Canis familiaris TSPYL2 VGNC VGNC:47928
Bos taurus TSPYL2 VGNC VGNC:36445
Macaca mulatta TSPYL2 VGNC VGNC:79433
Rattus norvegicus TSPYL2 RGD RGD:1563283
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