ABT1 - activator of basal transcription 1 Gene

中文名称：基础转录激活因子 1

种属: Homo sapiens

同用名: Esf2; hABT1

基因 ID: 29777 | 基因类型: protein coding

关于 ABT1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,596,953-26,600,739 (from NCBI)

This gene has 1 transcript (splice variant) and 194 orthologues. Ubiquitous expression in bone marrow (RPKM 4.4), lymph node (RPKM 3.9) and 25 other tissues.

功能概要

RNA 聚合酶 II 的基因基础转录需要 TATA 结合蛋白 (TBP) 与 II 类启动子的核心区域相互作用。小鼠研究表明，由该基因编码的蛋白质可能通过与 TBP 和 II 类启动子 DNA 的相互作用激活 II 类启动子的基础转录。[RefSeq 提供，2008 年 7 月]

Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

ABT1 基因产物(1)

mRNA	Protein	Name
NM_013375.4	NP_037507.1	activator of basal transcription 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19299493	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

activator of basal transcription 1

TATA-binding protein-binding protein

ABT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ABT1	Q9ULW3	CCDC136	Homo sapiens	Q96JN2-2	Y2H Array	25416956
Intra	ABT1	Q9ULW3	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	ABT1	Q9ULW3	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	ABT1	Q9ULW3	RNF151	Homo sapiens	Q2KHN1	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	RNF151	Homo sapiens	Q2KHN1	Y2H Array	32296183
Intra	ABT1	Q9ULW3	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	ABT1	Q9ULW3	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	EMD	Homo sapiens	P50402	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	EMD	Homo sapiens	P50402	Y2H Array	25416956
Intra	ABT1	Q9ULW3	EMD	Homo sapiens	P50402	Y2H Array	32296183
Intra	ABT1	Q9ULW3	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	ABT1	Q9ULW3	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	ABT1	Q9ULW3	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	ABT1	Q9ULW3	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	ABT1	Q9ULW3	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	ABT1	Q9ULW3	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	ABT1	Q9ULW3	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	ABT1	Q9ULW3	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	ABT1	Q9ULW3	TSPYL2	Homo sapiens	Q9H2G4	Anti Tag CoIP	33961781
Intra	ABT1	Q9ULW3	TSPYL2	Homo sapiens	Q9H2G4	Y2H Array	32296183
Intra	ABT1	Q9ULW3	TSPYL2	Homo sapiens	Q9H2G4	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1

Smard1	DSMA1
Sianrf	Dhmn6
Spinal Muscular Atrophy With Respiratory Distress 1	HMN6
Severe Infantile Axonal Neuropathy With Respiratory Failure	Autosomal Recessive Distal Spinal Muscular Atrophy 1
Diaphragmatic Spinal Muscular Atrophy	Spinal Muscular Atrophy With Respiratory Distress Type 1
Neuronopathy, Distal Hereditary Motor, Type Vi	Hmn Vi
Neuronopathy, Severe Infantile Axonal, With Respiratory Failure	Distal Spinal Muscular Atrophy 1
Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress	Distal Hereditary Motor Neuropathy Type 6
Distal-Hmn Type 6	Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1
Spinal Muscular Atrophy, Diaphragmatic	Distal Hereditary Motor Neuronopathy Type Vi
Distal Spinal Muscular Atrophy Type 1	Hmnvi
Spinal Muscular Atrophy With Respiratory Distress	Autosomal Recessive Distal Spinal Muscular Atrophy Type 1
Neuronopathy, Distal Hereditary Motor, 6	Dhmn Vi
Distal Hereditary Motor Neuropathy Type Vi	Severe Infantile Axonal Neuronopathy With Respiratory Failure
Spinal Muscular Atrophy Distal Autosomal Recessive 1	Atrophy, Muscular, Spinal, Distal, Type 1

Autosomal Recessive Distal Hereditary Motor Neuronopathy

Autosomal Recessive Distal Spinal Muscular Atrophy

Spinocerebellar Ataxia 17

Spinocerebellar Ataxia Type 17	SCA17
Huntington Disease-Like 4	Hdl4
Olivopontocerebellar Atrophy V	Cerebelloparenchymal Disorder Ii
Opca5	Cpd2
Sca 17	Ataxia, Spinocerebellar, Type 17

Acute Diarrhea

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00114	ABT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ABT1	VGNC	VGNC:102372
Rattus norvegicus	ABT1	RGD	RGD:1310785
Mus musculus	ABT1	MGD	MGI:1353636
Bos taurus	ABT1	VGNC	VGNC:25514
Macaca mulatta	ABT1	VGNC	VGNC:69448
Canis familiaris	ABT1	VGNC	VGNC:37485
Others	ABT1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4