2. Gene
  3. ZSCAN4 - zinc finger and SCAN domain containing 4 Gene

ZSCAN4 - zinc finger and SCAN domain containing 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指和 SCAN 域 4

种属: Homo sapiens

同用名: ZNF494

基因 ID: 201516 | 基因类型: protein coding

关于 ZSCAN4

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,651,476-57,679,152 (from NCBI)

This gene has 1 transcript (splice variant), 31 orthologues and 31 paralogues. Low expression observed in reference dataset.

功能概要

ZSCAN4 基因编码一种参与端粒维护的蛋白质，在小鼠胚胎干 (ES) 细胞的关键特征中发挥关键作用，即抵抗细胞衰老并维持培养中许多细胞分裂的正常核型 (Zalzman 等人，2010 年) [PubMed 20336070]) .[OMIM 提供，2010 年 5 月]

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

ZSCAN4 基因产物(2)

mRNA Protein Name
NM_001384833.1 NP_001371762.1 zinc finger and SCAN domain-containing protein 4
NM_152677.4 NP_689890.1 zinc finger and SCAN domain-containing protein 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZSCAN4 蛋白结构

SCAN

SCAN: SCAN domain (40 - 129)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (326 - 349)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (354 - 379)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (382 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
蛋白主名 其他名称

zinc finger and SCAN domain-containing protein 4

zinc finger protein 494

ZSCAN4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZSCAN4 Q8NAM6 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra ZSCAN4 Q8NAM6 LAMTOR3 Homo sapiens Q9UHA4
Validated Y2H
32296183
Intra ZSCAN4 Q8NAM6 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra ZSCAN4 Q8NAM6 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra ZSCAN4 Q8NAM6 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra ZSCAN4 Q8NAM6 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra ZSCAN4 Q8NAM6 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra ZSCAN4 Q8NAM6 EXOC8 Homo sapiens Q8IYI6
Y2H Prey Pooling
32296183
Intra ZSCAN4 Q8NAM6 EXOC8 Homo sapiens Q8IYI6
Y2H Array
32296183
Intra ZSCAN4 Q8NAM6 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy

Fshd

Landouzy-Dejerine Muscular Dystrophy

Muscular Dystrophy, Facioscapulohumeral

FSHD1

Fshd1a

Muscular Dystrophy, Facioscapulohumeral, Type 1a

Facioscapulohumeral Muscular Dystrophy Type 1a

Fsh Muscular Dystrophy

Facioscapulohumeral Muscular Dystrophy 1a

Facioscapulohumeral Atrophy

Facioscapulohumeral Myopathy

Muscular Dystrophy, Facioscapulohumeral, Type 1

Facioscapulohumeral Muscular Dystrophy Type 1

Landouzy Dejerine Muscular Dystrophy

Muscular Dystrophy, Landouzy-Dejerine

Fshmd1a

Facio-Scapulo-Humeral Dystrophy

Facioscapulohumeral Type Progressive Muscular Dystrophy

Facioscapuloperoneal Muscular Dystrophy

Facioscapulohumeral Dystrophy

Fsh Dystrophy

Landouzy-Dejerine Dystrophy

Landouzy-Dejerine Myopathy

Fmd

Facioscapulohumeral Muscular Dystrophy-1a

Muscular Dystrophy Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral, Type 1

Landouzy-Dejerine Disease

Landouzy-Déjerine Atrophy

Facioscapulohumeral Muscle Dystrophy

Fmd - [Facioscapulohumeral Muscular Dystrophy]

Fsh - [Facioscapulohumeral Muscular Dystrophy]

Fshd - [Facioscapulohumeral Muscular Dystrophy]

Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy 2

FSHD2

Fshd1b

Facioscapulohumeral Muscular Dystrophy 1b

Fshd2, Digenic

Muscular Dystrophy, Facioscapulohumeral, Type 2

Muscular Dystrophy, Facioscapulohumeral, Type 1b

Fascioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy Type 2

Digenic Facioscapulohumeral Muscular Dystrophy

Digenic Fshd2

Facioscapulohumeral Muscular Dystrophy Type 1b

Dystrophy, Muscular, Facioscapulohumeral, Type 2
Digenic Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16202 ZSCAN4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZSCAN4 RGD RGD:1563625
Bos taurus ZSCAN4 VGNC VGNC:52275
Macaca mulatta ZSCAN4 VGNC VGNC:79403
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