2. Gene
  3. RAC3 - Rac family small GTPase 3 Gene

RAC3 - Rac family small GTPase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rac 家族小 GTPase 3

种属: Homo sapiens

基因 ID: 5881 | 基因类型: protein coding

关于 RAC3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,031,678-82,034,204 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 10.2), brain (RPKM 6.3) and 22 other tissues.

功能概要

该基因编码的蛋白质是一种 GTP 酶，属于小 GTP 结合蛋白的 Ras 超家族。这个超家族的成员似乎调节一系列不同的细胞事件，包括细胞生长的控制、细胞骨架的重组和蛋白激酶的激活。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 10 月]

The protein encoded by this gene is a GTPase which belongs to the Ras superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

RAC3 基因产物(2)

mRNA Protein Name
NM_001316307.2 NP_001303236.1 ras-related C3 botulinum toxin substrate 3 isoform 2
NM_005052.3 NP_005043.1 ras-related C3 botulinum toxin substrate 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
11956649 GOA
enables calcium-dependent protein binding IPI
IPI: 通过物理相互作用推断
11756406 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11956649 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Wnt signaling pathway IMP
IMP: 通过突变表型推断
29276006 GOA
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
11956649 GOA
involved in cell projection assembly IDA
IDA: 通过直接分析推断
11956649 GOA
involved in positive regulation of cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
11756406 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IDA
IDA: 通过直接分析推断
11756406 GOA
involved in postsynaptic actin cytoskeleton organization IDA
IDA: 通过直接分析推断
21297961 GOA
involved in postsynaptic actin cytoskeleton organization IMP
IMP: 通过突变表型推断
21297961 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
11756406 GOA
located in endomembrane system IDA
IDA: 通过直接分析推断
11956649 GOA
part of filamentous actin IDA
IDA: 通过直接分析推断
16525025 GOA
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21297961 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21297961 GOA
located in growth cone IDA
IDA: 通过直接分析推断
16525025 GOA
located in neuron projection IDA
IDA: 通过直接分析推断
16525025 GOA
located in neuronal cell body IDA
IDA: 通过直接分析推断
16525025 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11756406 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAC3 蛋白结构

Ras

Ras: Ras family (5 - 177)

  • 0
  • 100
  • 192 a.a.
蛋白主名 其他名称

ras-related C3 botulinum toxin substrate 3

p21-Rac3

RAC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAC3 P60763 HDAC7 Homo sapiens Q8WUI4-6
Validated Y2H
32296183
Intra RAC3 P60763 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra RAC3 P60763 NRBP1 Homo sapiens Q9UHY1
Anti Tag CoIP
11956649
Intra RAC3 P60763 ESR1 Homo sapiens P03372
Phage Display
21217774
Intra RAC3 P60763 ESR1 Homo sapiens P03372
Y2H
21217774
Intra RAC3 P60763 ESR1 Homo sapiens P03372
Pull Down
21217774
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Structural Brain Anomalies And Dysmorphic Facies

NEDBAF
Ascaridiasis

Ascariasis
Toxic Megacolon

Megacolon, Toxic

Toxic Dilatation Of Colon

Toxic Functional Megacolon
Deafness, Autosomal Recessive 104

DFNB104

Autosomal Recessive Nonsyndromic Deafness 104

Autosomal Recessive Deafness 104

Deafness, Autosomal Recessive, 104

Deafness, Autosomal Recessive, Type 104
Clostridium Difficile Colitis

Pseudomembranous Colitis

Colitis Pseudomembranous

Enterocolitis, Pseudomembranous

Pseudomembranous Enterocolitis

Clostridium Difficile Infection
Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia

Konigsmark Syndrome

DFNA1

Autosomal Dominant Nonsyndromic Deafness 1

Lfhl1

Deafness, Autosomal Dominant 1

Autosomal Dominant Deafness 1

Autosomal Dominant Deafness 1, With Or Without Thrombocytopenia

Hereditary Low Frequency Hearing Loss 1

Diaph1-Related Sensorineural Hearing Loss-Thrombocytopenia Syndrome

Diaph1-Related Sensorineural Deafness-Thrombocytopenia Syndrome

Hereditary Low-Frequency Hearing Loss

Hereditary Low-Frequency Sensorineural Hearing Loss

Lfsnhl1

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 1

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 1

Deafness, Autosomal Dominant, Type 1
Osteogenesis Imperfecta, Type Xv

Osteogenesis Imperfecta Type 15

OI15

Osteogenesis Imperfecta Type Xv

Oi, Type Xv

Osteogenesis Imperfecta 15

Oi Type Xv

Oi-Xv
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16659 EHT 1864 Inhibitor 99.85% 否
HY-12810 EHop-016 Inhibitor 99.85% 否
HY-132404S (rac)-3-O-Methyl DOPA-d3 98.73% 否
HY-113801 N-(3-Oxooctanoyl)-DL-homoserine lactone 99.15% 否
HY-136345 (Rac)-3′-Hydroxy simvastatin / 否
HY-RS11593 RAC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-100841 (Rac)-3-Hydroxyphenylglycine Inhibitor 99.58% 否
HY-W779204 rac-3-Hexadecanamido-2-methoxypropan-1-ol phosphocholine hydrate / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RAC3 VGNC VGNC:76642
Bos taurus RAC3 VGNC VGNC:55865
Felis catus RAC3 VGNC VGNC:99429
Rattus norvegicus RAC3 RGD RGD:1590052
Mus musculus RAC3 MGD MGI:2180784
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