A1CF - APOBEC1 complementation factor Gene

中文名称：APOBEC1 互补因子

种属: Homo sapiens

同用名: ACF; ASP; ACF64; ACF65; APOBEC1CF

关于 A1CF

功能概要

哺乳动物载脂蛋白 B mRNA 经历位点特异性 C 到 U 脱氨作用，这是由多组分酶复合物介导的，该酶复合物含有由 APOBEC-1 组成的最小核心和由该基因编码的互补因子。该基因产物具有三个不同的 RNA 识别基序，属于 RNA 结合蛋白的 hnRNP R 家族。有人提出，这种互补因子作为 RNA 结合亚基发挥作用，并停靠 APOBEC-1 使上游胞苷脱氨。研究表明该蛋白质还可能参与其他 RNA 编辑或 RNA 加工事件。已发现该基因的几种转录变体编码几种不同的亚型。[RefSeq 提供，2010 年 11 月]

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component Enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]