1. Gene
  2. OLIG3 - oligodendrocyte transcription factor 3 Gene

OLIG3 - oligodendrocyte transcription factor 3 Gene

中文名称:少突胶质细胞转录因子 3

种属: Homo sapiens

同用名: Bhlhb7; bHLHe20

基因 ID: 167826 | 基因类型: protein coding

关于 OLIG3

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:137,492,199-137,494,394 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 15 paralogues.

功能概要

启用序列特异性双链 DNA 结合活性。预计通过 RNA 聚合酶 II 参与神经元分化和转录调节。预计在 RNA 聚合酶 II 的转录负调节上游或负调节内起作用;脊髓运动神经元细胞命运规范;和脊髓运动神经元迁移。预测是染色质的一部分。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OLIG3 基因产物(1)

mRNA Protein Name
NM_175747.2 NP_786923.1 oligodendrocyte transcription factor 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OLIG3 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (85 - 137)

  • 0
  • 100
  • 200
  • 272 a.a.
蛋白主名 其他名称

oligodendrocyte transcription factor 3

class B basic helix-loop-helix protein 7

OLIG3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OLIG3 Q7RTU3 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
种属内
OLIG3 Q7RTU3 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
种属内
OLIG3 Q7RTU3 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
种属内
OLIG3 Q7RTU3 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 ATN1 Homo sapiens Q86V38
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 ATN1 Homo sapiens Q86V38
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 ATN1 Homo sapiens Q86V38
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 RUNX1 Homo sapiens Q01196-8
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 RUNX1 Homo sapiens Q01196-8
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 BYSL Homo sapiens Q13895
Y2H Array
25416956
种属内
OLIG3 Q7RTU3 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
种属内
OLIG3 Q7RTU3 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
种属内
OLIG3 Q7RTU3 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
种属内
OLIG3 Q7RTU3 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
种属内
OLIG3 Q7RTU3 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
OLIG3 Q7RTU3 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
OLIG3 Q7RTU3 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
OLIG3 Q7RTU3 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 MDFI Homo sapiens Q99750
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 MDFI Homo sapiens Q99750
Validated Y2H
25416956
种属内
OLIG3 Q7RTU3 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
种属内
OLIG3 Q7RTU3 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 PROP1 Homo sapiens O75360
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 PROP1 Homo sapiens O75360
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属内
OLIG3 Q7RTU3 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
种属内
OLIG3 Q7RTU3 KRT86 Homo sapiens O43790
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Congenital Central Hypoventilation Syndrome

Cchs

Haddad Syndrome

Ondine Curse

Ondine Syndrome

Congenital Central Hypoventilation

Congenital Central Alveolar Hypoventilation Syndrome

Congenital Failure Of Autonomic Control

Ondine'S Curse

Primary Alveolar Hypoventilation

Ondine-Hirschsprung Disease

Central Congenital Hypoventilation Syndrome

Congenital Ondine Curse

Idiopathic Congenital Central Alveolar Hypoventilation

Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

Ondine-Hirschsprung Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus OLIG3 MGD MGI:2149955
Bos taurus OLIG3 VGNC VGNC:32426
Macaca mulatta OLIG3 VGNC VGNC:83439
Rattus norvegicus OLIG3 RGD RGD:1305997
Canis familiaris OLIG3 VGNC VGNC:44119
Felis catus OLIG3 VGNC VGNC:63966