2. Gene
  3. CENPV - centromere protein V Gene

CENPV - centromere protein V Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：着丝粒蛋白 V

种属: Homo sapiens

同用名: p30; PRR6; CENP-V; 3110013H01Rik

基因 ID: 201161 | 基因类型: protein coding

关于 CENPV

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:16,342,537-16,353,469 (from NCBI)

This gene has 7 transcripts (splice variants), 180 orthologues and 3 paralogues. Broad expression in small intestine (RPKM 17.0), duodenum (RPKM 16.5) and 25 other tissues.

功能概要

预测可启用碳硫裂解酶活性和金属离子结合活性。参与中心异染色质组装；胞质分裂的正调节；和染色体组织的调节。在变形虫型细胞迁移的上游或内部起作用。位于多个细胞成分中，包括中体；核;和主轴中间区。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Involved in pericentric heterochromatin assembly; positive regulation of cytokinesis; and regulation of chromosome organization. Acts upstream of or within ameboidal-type cell migration. Located in several cellular components, including midbody; nucleus; and spindle midzone. [provided by Alliance of Genome Resources, Apr 2022]

CENPV 基因产物(1)

mRNA Protein Name
NM_181716.3 NP_859067.2 centromere protein V
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ameboidal-type cell migration IDA
IDA: 通过直接分析推断
19930468 GOA
involved in centromere complex assembly IMP
IMP: 通过突变表型推断
18772885 GOA
involved in pericentric heterochromatin formation IMP
IMP: 通过突变表型推断
18772885 GOA
involved in positive regulation of cytokinesis IMP
IMP: 通过突变表型推断
18772885 GOA
involved in regulation of chromosome organization IMP
IMP: 通过突变表型推断
18772885 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in kinetochore IDA
IDA: 通过直接分析推断
18772885 GOA
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
19930468 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12196509 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
18772885 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CENPV 蛋白结构

GFA

GFA: Glutathione-dependent formaldehyde-activating enzyme (168 - 241)

  • 0
  • 100
  • 200
  • 272 a.a.
蛋白主名 其他名称

centromere protein V

nuclear protein p30

CENPV 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CENPV Q7Z7K6 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
种属内
CENPV Q7Z7K6 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
种属内
CENPV Q7Z7K6 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
种属内
CENPV Q7Z7K6 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
种属内
CENPV Q7Z7K6 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
种属内
CENPV Q7Z7K6 HTRA2 Homo sapiens O43464
Y2H Array
32814053
种属内
CENPV Q7Z7K6 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
CENPV Q7Z7K6 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
CENPV Q7Z7K6 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
CENPV Q7Z7K6 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
种属内
CENPV Q7Z7K6 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
种属内
CENPV Q7Z7K6 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
种属内
CENPV Q7Z7K6 PRPH Homo sapiens P41219
Validated Y2H
32814053
种属内
CENPV Q7Z7K6 PRPH Homo sapiens P41219
Y2H Pooling
32814053
种属内
CENPV Q7Z7K6 PRPH Homo sapiens P41219
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Histoplasmosis Retinitis

Histoplasmosis With Retinitis
Central Nervous System Hemangioma

Hemangioma Of Cns

Hemangioma Of The Central Nervous System
Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm
Diffuse Glomerulonephritis

Glomerulonephritis Diffuse
T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma

Adult Precursor T Lymphoblastic Leukemia

Atll

T-Cell Adult Acute Lymphoblastic Leukemia
Askin'S Tumor

Askin Tumor

Askin Tumour

Askin'S Tumour
Extraosseous Ewing Sarcoma

Extraosseous Ewing'S Sarcoma

Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Extraskeletal Ewing Sarcom

Sarcoma Extraosseous Ewings

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia
Ehrlichiosis

Human Ehrlichiosis

He

Hey
Tropical Spastic Paraparesis

Tropical Spastic Paraplegia

Ham/Tsp

Htlv-Associated Myelopathy

Tropical Spastic Paralysis

Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis

Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis

Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis

Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis

Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis

Tsp

Paraparesis Tropical Spastic

Paraparesis, Tropical Spastic
Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02493 CENPV Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CENPV MGD MGI:1920389
Rattus norvegicus CENPV RGD RGD:1565681
Bos taurus CENPV VGNC VGNC:107269
Canis familiaris CENPV VGNC VGNC:53316
Macaca mulatta CENPV VGNC VGNC:99137
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