MARK2 - microtubule affinity regulating kinase 2 Gene

中文名称：微管亲和调节激酶 2

种属: Homo sapiens

同用名: EMK1; EMK-1; PAR-1; Par1b; Par-1b

基因 ID: 2011 | 基因类型: protein coding

关于 MARK2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,839,110-63,911,020 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶 Par-1 家族的成员。该蛋白质是上皮细胞和神经元细胞中细胞极性的重要调节剂，并且还通过几种微管相关蛋白的磷酸化和失活来控制微管的稳定性。蛋白质定位于细胞膜。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 7 月]

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

MARK2 基因产物(5)

mRNA	Protein	Name
NM_001039469.3	NP_001034558.2	serine/threonine-protein kinase MARK2 isoform d
NM_001163296.2	NP_001156768.1	serine/threonine-protein kinase MARK2 isoform e
NM_001163297.2	NP_001156769.1	serine/threonine-protein kinase MARK2 isoform f
NM_004954.5	NP_004945.4	serine/threonine-protein kinase MARK2 isoform c
NM_017490.4	NP_059672.2	serine/threonine-protein kinase MARK2 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	14976552	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	14976552	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14676191	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	14976552	GOA
enables tau-protein kinase activity	IMP IMP: 通过突变表型推断	23666762	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in establishment of cell polarity	IDA IDA: 通过直接分析推断	12429843	GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity	IDA IDA: 通过直接分析推断	15324659	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	14976552	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	10542369	GOA
involved in positive regulation of neuron projection development	IDA IDA: 通过直接分析推断	12429843	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	14976552	GOA
involved in protein phosphorylation	IMP IMP: 通过突变表型推断	23666762	GOA
involved in regulation of axonogenesis	IMP IMP: 通过突变表型推断	20194617	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: 通过直接分析推断	10542369	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin filament	IDA IDA: 通过直接分析推断	23902687	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	23666762	GOA
located in dendrite	IDA IDA: 通过直接分析推断	23666762	GOA
located in lateral plasma membrane	IDA IDA: 通过直接分析推断	23902687	GOA
located in membrane	IMP IMP: 通过突变表型推断	14976552	GOA
located in microtubule bundle	IDA IDA: 通过直接分析推断	23902687	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	23902687	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MARK2 蛋白结构

Pkinase

KA1

0
200
400
600
788 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase MARK2

ELKL motif kinase 1

MARK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MARK2	Q7KZI7	PARD6G	Homo sapiens	Q9BYG4	Anti Tag CoIP	14676191
种属内	MARK2	Q7KZI7	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
种属内	MARK2	Q7KZI7	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
种属内	MARK2	Q7KZI7	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	19615732
种属内	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	TAP	16306228
种属内	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	Pull Down	32707033
种属内	MARK2	Q7KZI7	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	35271311
种属内	MARK2	Q7KZI7	YWHAB	Homo sapiens	P31946	Pull Down	32707033
种属内	MARK2	Q7KZI7	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	16959763
种属内	MARK2	Q7KZI7	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	35271311
种属内	MARK2	Q7KZI7	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
种属内	MARK2	Q7KZI7	YWHAG	Homo sapiens	P61981	Pull Down	32707033
种属内	MARK2	Q7KZI7	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	16959763
种属间	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	X-Ray Diffraction	19966800
种属间	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	GMS	19966800
种属间	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	Pull Down	19966800
种属间	MARK2	Q7KZI7	cagA	Helicobacter pylori	P55980	SLCA	19966800

种属间: 跨种属相互作用 种属内: 同种属相互作用

MARK2 抗体

目录号	产品名	应用	反应物种
HY-P82359	MARK2 Antibody (YA2104)	WB, FC	Human, Mouse, Rat

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120877	MRT199665		99.74%	否
HY-139604	PCC0208017		99.56%	否
HY-148062	RSS0680		98.03%	否
HY-120877A	(R)-MRT199665		98.70%	否
HY-RS08150	MARK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MARK2	VGNC	VGNC:74634
Canis familiaris	MARK2	VGNC	VGNC:43024
Mus musculus	MARK2	MGD	MGI:99638
Bos taurus	MARK2	VGNC	VGNC:31248
Rattus norvegicus	MARK2	RGD	RGD:708483
Felis catus	MARK2	VGNC	VGNC:63389

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