MAP3K3 - mitogen-activated protein kinase kinase kinase 3 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 3

种属: Homo sapiens

同用名: MEKK3; MAPKKK3

基因 ID: 4215 | 基因类型: protein coding

关于 MAP3K3

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,622,417-63,696,305 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 15.4), lung (RPKM 14.5) and 25 other tissues.

功能概要

该基因产物是一个 626 个氨基酸的多肽，与小鼠 Mekk3 有 96.5% 的同一性。它的催化结构域与其他几种激酶密切相关，包括小鼠 Mekk2、烟草 NPK 和酵母 Ste11。 Northern 印迹分析揭示了一个似乎普遍表达的 4.6-kb 转录物。该蛋白分别通过激活 SEK 和 MEK1/2 直接调节应激激活蛋白激酶 (SAPK) 和细胞外信号调节蛋白激酶 (ERK) 通路；它不调节 p38 通路。在共转染测定中，它增强了核因子 kappa-B (NFKB) 依赖性报告基因的转录，这与 SAPK 通路中的作用一致。已经观察到编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several Other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

MAP3K3 基因产物(4)

mRNA	Protein	Name
NM_001330431.2	NP_001317360.1	mitogen-activated protein kinase kinase kinase 3 isoform 3
NM_001363768.2	NP_001350697.1	mitogen-activated protein kinase kinase kinase 3 isoform 4
NM_002401.5	NP_002392.2	mitogen-activated protein kinase kinase kinase 3 isoform 2
NM_203351.3	NP_976226.1	mitogen-activated protein kinase kinase kinase 3 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12392720	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	15001576	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within intracellular signal transduction	IDA IDA: 通过直接分析推断	15001576	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: 通过表达模式推断	12761501	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: 通过直接分析推断	15001576	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP3K3 蛋白结构

PB1

Pkinase

0
100
200
300
400
500
626 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase kinase kinase 3

MAP/ERK kinase kinase 3

MAP3K3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAP3K3	Q99759	YWHAH	Homo sapiens	Q04917	TAP	14743216
种属内	MAP3K3	Q99759	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
种属内	MAP3K3	Q99759	MAP2K5	Homo sapiens	Q13163	Pull Down	32707033
种属内	MAP3K3	Q99759	MAP2K5	Homo sapiens	Q13163	PLA	25241761
种属内	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	Imaging	14743216
种属内	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	Anti Tag CoIP	14743216
种属内	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	TAP	14743216
种属内	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	Pull Down	32707033
种属内	MAP3K3	Q99759	TRAF7	Homo sapiens	Q6Q0C0	CoIP	15001576
种属内	MAP3K3	Q99759	YWHAZ	Homo sapiens	P63104	TAP	14743216
种属内	MAP3K3	Q99759	YWHAE	Homo sapiens	P62258	TAP	14743216
种属内	MAP3K3	Q99759	YWHAE	Homo sapiens	P62258	CoIP	12392720
种属内	MAP3K3	Q99759	YWHAE	Homo sapiens	P62258	Pull Down	16407301
种属内	MAP3K3	Q99759	YWHAB	Homo sapiens	P31946	CoIP	18308725
种属内	MAP3K3	Q99759	YWHAB	Homo sapiens	P31946	TAP	14743216
种属内	MAP3K3	Q99759	YWHAG	Homo sapiens	P61981	TAP	14743216
种属内	MAP3K3	Q99759	YWHAG	Homo sapiens	P61981	Pull Down	32707033
种属内	MAP3K3	Q99759	YWHAQ	Homo sapiens	P27348	TAP	14743216

种属间: 跨种属相互作用 种属内: 同种属相互作用

MAP3K3 抗体

目录号	产品名	应用	反应物种
HY-P82888	MEKK3 Antibody (YA2633)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Verrucous Hemangioma

Verrucous Keratotic Hemangioma

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Ciliary Dyskinesia, Primary, 20

Primary Ciliary Dyskinesia 20	CILD20
Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus
Ics20	Immotile Cilia Syndrome 20
Dyskinesia, Ciliary, Primary, 20

Non-Syndromic X-Linked Intellectual Disability 107

Mrx107

X-Linked Mental Retardation 107

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Senile Angioma

Senile Hemangioma

Senile Naevus Of Skin

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome	KTS
Ktw Syndrome	Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome	Klippel Trenaunay Syndrome
Klippel-Trénaunay-Weber Syndrome	Haemangiectatic Hypertrophy
Weber-Klippel-Trenaunay	Congenital Dysplastic Angiopathy
Klippel-Trenaunay Disease	Weber Klippel Trenaunay

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08056	MAP3K3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MAP3K3	VGNC	VGNC:42973
Bos taurus	MAP3K3	VGNC	VGNC:31196
Rattus norvegicus	MAP3K3	RGD	RGD:1304575
Macaca mulatta	MAP3K3	VGNC	VGNC:81462
Mus musculus	MAP3K3	MGD	MGI:1346874
Felis catus	MAP3K3	VGNC	VGNC:97495

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