2. Gene
  3. MAP2K5 - mitogen-activated protein kinase kinase 5 Gene

MAP2K5 - mitogen-activated protein kinase kinase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶 5

种属: Homo sapiens

同用名: MEK5; MAPKK5; PRKMK5; HsT17454

基因 ID: 5607 | 基因类型: protein coding

关于 MAP2K5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:67,542,703-67,807,114 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 2.0), testis (RPKM 1.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种双特异性蛋白激酶，属于 MAP 激酶激酶家族。该激酶特异性地与 MAPK7/ERK5 相互作用并激活 MAPK7/ERK5。这种激酶本身可以被 MAP3K3/MEKK3 以及非典型蛋白激酶 C 亚型 (aPKC) 磷酸化和激活。由该激酶介导的信号级联涉及生长因子刺激的细胞增殖和肌肉细胞分化。已经描述了编码不同同种型的该基因的三个可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

MAP2K5 基因产物(10)

mRNA Protein Name
XM_011521788.4 XP_011520090.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X2
XM_017022414.3 XP_016877903.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X3
NM_002757.4 NP_002748.1 dual specificity mitogen-activated protein kinase kinase 5 isoform B
XM_011521787.4 XP_011520089.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X1
XM_047432856.1 XP_047288812.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X4
NM_145162.1
NM_145160.3 NP_660143.1 dual specificity mitogen-activated protein kinase kinase 5 isoform A
NM_001206804.2 NP_001193733.1 dual specificity mitogen-activated protein kinase kinase 5 isoform C
NM_145161.1
XR_007064474.1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7759517 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP2K5 蛋白结构

PB1

PB1: PB1 domain (19 - 88)

Pkinase

Pkinase: Protein kinase domain (169 - 419)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
蛋白主名 其他名称

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5

MAP kinase kinase MEK5b

MAPK/ERK kinase 5

MAPKK 5

MEK 5

MAP2K5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP2K5 Q13163 GUCD1 Homo sapiens Q96NT3-2
Validated Y2H
32296183
种属内
MAP2K5 Q13163 GUCD1 Homo sapiens Q96NT3-2
Y2H Array
32296183
种属内
MAP2K5 Q13163 GUCD1 Homo sapiens Q96NT3-2
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Pull Down
32707033
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Anti Tag CoIP
28514442
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Y2H
7759517
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Validated Y2H
32296183
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Anti Tag CoIP
33961781
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Pull Down
7759517
种属内
MAP2K5 Q13163 MAPK7 Homo sapiens Q13164
Y2H Array
32296183
种属内
MAP2K5 Q13163 C3orf36 Homo sapiens Q3SXR2
Y2H Array
32296183
种属内
MAP2K5 Q13163 C3orf36 Homo sapiens Q3SXR2
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 C3orf36 Homo sapiens Q3SXR2
Validated Y2H
32296183
种属内
MAP2K5 Q13163 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
种属内
MAP2K5 Q13163 LNX2 Homo sapiens Q8N448
Y2H
21516116
种属内
MAP2K5 Q13163 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
种属内
MAP2K5 Q13163 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
31980649
种属内
MAP2K5 Q13163 SQSTM1 Homo sapiens Q13501
Validated Y2H
32296183
种属内
MAP2K5 Q13163 SQSTM1 Homo sapiens Q13501
Y2H Array
32296183
种属内
MAP2K5 Q13163 MAP3K3 Homo sapiens Q99759
Pull Down
32707033
种属内
MAP2K5 Q13163 MAP3K3 Homo sapiens Q99759
Anti Tag CoIP
33961781
种属内
MAP2K5 Q13163 MAP3K3 Homo sapiens Q99759
TAP
14743216
种属内
MAP2K5 Q13163 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
MAP2K5 Q13163 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
种属内
MAP2K5 Q13163 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
种属内
MAP2K5 Q13163 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
种属内
MAP2K5 Q13163 MAP3K2 Homo sapiens Q9Y2U5
Pull Down
32707033
种属内
MAP2K5 Q13163 MAP3K2 Homo sapiens Q9Y2U5
Anti Tag CoIP
31980649
种属内
MAP2K5 Q13163 MAP3K2 Homo sapiens Q9Y2U5
Anti Tag CoIP
33961781
种属内
MAP2K5 Q13163 MAP3K2 Homo sapiens Q9Y2U5
Anti Tag CoIP
28514442
种属内
MAP2K5 Q13163 GRB2 Homo sapiens P62993
Peptide Array
17474147
种属内
MAP2K5 Q13163 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
种属内
MAP2K5 Q13163 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
种属内
MAP2K5 Q13163 DUSP21 Homo sapiens Q9H596
Validated Y2H
32296183
种属内
MAP2K5 Q13163 DUSP21 Homo sapiens Q9H596
Y2H Array
32296183
种属内
MAP2K5 Q13163 DUSP21 Homo sapiens Q9H596
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 ZNF426 Homo sapiens Q9BUY5
Y2H Prey Pooling
32296183
种属内
MAP2K5 Q13163 ZNF426 Homo sapiens Q9BUY5
Y2H Array
32296183
种属内
MAP2K5 Q13163 ZNF426 Homo sapiens Q9BUY5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

MAP2K5 抗体

目录号 产品名 应用 反应物种
HY-P83395 MEK5 Antibody (YA3140) WB, ICC/IF Human

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To
Cavernous Hemangioma

Hemangioma, Cavernous

Cavernoma

Cavernous Haemangioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08041 MAP2K5 Human Pre-designed siRNA Set A / 否
HY-RS08042 Map2k5 Mouse Pre-designed siRNA Set A / 否
HY-RS08043 Map2k5 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAP2K5 RGD RGD:61890
Mus musculus MAP2K5 MGD MGI:1346345
Felis catus MAP2K5 VGNC VGNC:104488
Canis familiaris MAP2K5 VGNC VGNC:42963
Macaca mulatta MAP2K5 VGNC VGNC:81455
Bos taurus MAP2K5 VGNC VGNC:31186
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z