MAP3K2 - mitogen-activated protein kinase kinase kinase 2 Gene

中文名称：丝裂原活化蛋白激酶激酶 2

种属: Homo sapiens

同用名: MEKK2; MEKK2B

基因 ID: 10746 | 基因类型: protein coding

关于 MAP3K2

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,298,668-127,388,465 (from NCBI)

This gene has 3 transcripts (splice variants), 217 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 11.2), thyroid (RPKM 10.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的成员。该激酶优先激活其他参与 MAP 激酶信号通路的激酶。该激酶已被证明可直接磷酸化和激活 Ikappa B 激酶，因此在 NF-kappa B 信号通路中发挥作用。还发现这种激酶结合并激活蛋白激酶 C 相关激酶 2，这表明它参与了受调节的信号传导过程。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates Other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

MAP3K2 基因产物(3)

mRNA	Protein	Name
NM_001371910.2	NP_001358839.1	mitogen-activated protein kinase kinase kinase 2
NM_001371911.1	NP_001358840.1	mitogen-activated protein kinase kinase kinase 2
NM_006609.5	NP_006600.3	mitogen-activated protein kinase kinase kinase 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15778465	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	15001576	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	17906693	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to mechanical stimulus	IEP IEP: 通过表达模式推断	19593445	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	14515274	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP3K2 蛋白结构

PB1

Pkinase

0
100
200
300
400
500
619 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase kinase kinase 2

MAP/ERK kinase kinase 2

MAP3K2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAP3K2	Q9Y2U5	MAP2K5	Homo sapiens	Q13163	Y2H Array	21988832
种属内	MAP3K2	Q9Y2U5	MAP2K5	Homo sapiens	Q13163	Pull Down	32707033
种属内	MAP3K2	Q9Y2U5	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	MAP3K2	Q9Y2U5	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	26496610
种属内	MAP3K2	Q9Y2U5	YWHAE	Homo sapiens	P62258	Pull Down	32707033
种属内	MAP3K2	Q9Y2U5	STUB1	Homo sapiens	Q9UNE7	Anti Tag CoIP	20588253
种属内	MAP3K2	Q9Y2U5	STUB1	Homo sapiens	Q9UNE7	Anti Bait CoIP	20588253
种属内	MAP3K2	Q9Y2U5	SFN	Homo sapiens	P31947	TAP	15778465
种属内	MAP3K2	Q9Y2U5	SFN	Homo sapiens	P31947	Anti Tag CoIP	26496610

种属间: 跨种属相互作用 种属内: 同种属相互作用

MAP3K2 抗体

目录号	产品名	应用	反应物种
HY-P83470	MEKK2 Antibody (YA3215)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-112080A	(R)-BAY-6035		/	否
HY-RS08054	MAP3K2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MAP3K2	VGNC	VGNC:42972
Macaca mulatta	MAP3K2	VGNC	VGNC:81461
Mus musculus	MAP3K2	MGD	MGI:1346873
Rattus norvegicus	MAP3K2	RGD	RGD:620967
Felis catus	MAP3K2	VGNC	VGNC:80275
Bos taurus	MAP3K2	VGNC	VGNC:31195
Others	MAP3K2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MAP3K2 - mitogen-activated protein kinase kinase kinase 2 Gene

关于 MAP3K2

功能概要

MAP3K2 基因产物(3)

MAP3K2 蛋白结构

MAP3K2 蛋白互作信息

MAP3K2 抗体

关联疾病

直系同源

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MAP3K2 - mitogen-activated protein kinase kinase kinase 2 Gene

关于 MAP3K2

功能概要

MAP3K2 基因产物(3)

MAP3K2 蛋白结构

MAP3K2 蛋白互作信息

MAP3K2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z