TRAF7 - TNF receptor associated factor 7 Gene

中文名称：TNF 受体相关因子 7

种属: Homo sapiens

同用名: RFWD1; RNF119; CAFDADD

基因 ID: 84231 | 基因类型: protein coding

关于 TRAF7

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,155,782-2,178,129 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues, 14 paralogues and is associated with 100 phenotypes. Ubiquitous expression in duodenum (RPKM 19.0), esophagus (RPKM 17.7) and 25 other tissues.

功能概要

肿瘤坏死因子 (TNF；见 MIM 191160) 受体相关因子，如 TRAF7，是 TNF 受体超家族成员的信号转导 (见 MIM 191190) 。 TRAF 由含有锌环和/或锌指基序的 N 末端富含半胱氨酸/组氨酸的区域组成；盘绕线圈 (亮氨酸拉链) 图案；以及定义 TRAF 家族的同源区域，即 TRAF 结构域，它参与自结合和受体结合。[OMIM 提供，2004 年 4 月]

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF Receptor Superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

TRAF7 基因产物(1)

mRNA	Protein	Name
NM_032271.3	NP_115647.2	E3 ubiquitin-protein ligase TRAF7

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14743216	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	21518757	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	14743216	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within apoptotic process	IDA IDA: 通过直接分析推断	15001576	GOA
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	15001576	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	14743216	GOA
involved in positive regulation of apoptotic signaling pathway	IMP IMP: 通过突变表型推断	15001576	GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	21518757	GOA
involved in protein K29-linked ubiquitination	IDA IDA: 通过直接分析推断	21518757	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	14743216	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	29961569	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	14743216	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAF7 蛋白结构

zf-C3HC4_2

zf-TRAF

WD40

0
200
400
600
670 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase TRAF7

RING finger and WD repeat-containing protein 1

TRAF7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Cross	TRAF7	Q6Q0C0	Ripk4	Mus musculus	Q9ERK0	Anti Tag CoIP	21903422

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cardiac, Facial, And Digital Anomalies With Developmental Delay

CAFDADD

Traf7-Associated Heart Defect-Digital Anomalies-Facial Dysmorphism-Motor And Speech Delay Syndrome

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Skull Base Meningioma

Meningioma Of The Skull Base

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Adenomatoid Tumor

Adenomatoid Tumour	Benign Localised Epithelial Mesothelioma
Benign Localized Epithelial Mesothelioma

Anterior Cranial Fossa Meningioma

Meningioma Of The Anterior Fossa

Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove

Angiomatous Meningioma

Intraneural Perineurioma

Meningothelial Meningioma

Meningotheliomatous Meningioma

Secretory Meningioma

Meningioma

Chordoid Meningioma

Meningioma, Chordoid

Transitional Meningioma

Intraventricular Meningioma

Clear Cell Meningioma

Sphenoorbital Meningioma

Brain Meningioma

Intracranial Meningioma

Cerebral Convexity Meningioma

Cerebral Hemispheric Convexity Meningioma

Childhood Meningioma

Pediatric Meningioma

Rhabdoid Meningioma

Papillary Meningioma

Meningioma, Rhabdoid

Foramen Magnum Meningioma

Meningioma Of The Foramen Magnum

Cerebral Falx Meningioma

Falcine Meningioma

Falx Cerebri Meningioma

Spinal Meningioma

Spinal Cord Meningioma	Meningioma, Spine
Meningioma	Meningioma, Benign, No Icd-O Subtype

Spinal Canal And Spinal Cord Meningioma

Intracranial Meningioma

Meningioma

Psammomatous Meningioma

Fibrous Meningioma

Fibroblastic Meningioma

Parasagittal Meningioma

Cavernous Sinus Meningioma

Meningioma Of The Cavernous Sinus

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Microcystic Meningioma

Tuberculum Sellae Meningioma

Meningioma Of The Tuberculum Sellae

Sella Turcica Neoplasm

Tumor Of Sella Turcica

Petroclival Meningioma

Benign Meningioma

Meningioma, Benign

Cerebral Meningioma

Meningioma Of Cerebrum

Optic Nerve Sheath Meningioma

Meningioma Of Optic Nerve Sheath

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Spinal Cancer

Spinal Cord Neoplasm	Spinal Cord Neoplasms
Spinal Neoplasms	Intraspinal Tumor
Malignant Tumor Of The Spinal Cord	Spinal Cord Cancer
Spinal Neoplasm	Tumor Of The Spinal Cord
Tumors Spinal Cord	Intraspinal Neoplasm
Spinal Cord--Cancer

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

直系同源

种属	基因名	来源	基因 ID
Felis catus	TRAF7	VGNC	VGNC:66502
Rattus norvegicus	TRAF7	RGD	RGD:1559653
Canis familiaris	TRAF7	VGNC	VGNC:47770
Bos taurus	TRAF7	VGNC	VGNC:36279
Macaca mulatta	TRAF7	VGNC	VGNC:79252
Mus musculus	TRAF7	MGD	MGI:3042141

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRAF7 - TNF receptor associated factor 7 Gene

关于 TRAF7

功能概要

TRAF7 基因产物(1)

TRAF7 蛋白结构

TRAF7 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

TRAF7 - TNF receptor associated factor 7 Gene

关于 TRAF7

功能概要

TRAF7 基因产物(1)

TRAF7 蛋白结构

TRAF7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z