KLF12 - KLF transcription factor 12 Gene

中文名称：KLF 转录因子 12

种属: Homo sapiens

同用名: AP2REP; AP-2rep; HSPC122

关于 KLF12

功能概要

Activator protein-2 alpha (AP-2 alpha) 是一种发育调节的转录因子，也是脊椎动物发育和癌变过程中基因表达的重要调节因子。该基因编码的蛋白质是 Kruppel 样锌指蛋白家族的成员，可以通过与 AP-2 α 基因启动子中的特定位点结合来抑制 AP-2 α 基因的表达。编码蛋白的抑制需要与共阻遏物 CtBP1 结合。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]