MNDA - myeloid cell nuclear differentiation antigen Gene

中文名称：骨髓细胞核分化抗原

种属: Homo sapiens

同用名: PYHIN3

基因 ID: 4332 | 基因类型: protein coding

关于 MNDA

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,831,351-158,849,502 (from NCBI)

This gene has 3 transcripts (splice variants), 48 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 108.7), appendix (RPKM 52.2) and 7 other tissues.

功能概要

髓样细胞核分化抗原 (MNDA) 仅在粒细胞-单核细胞谱系的细胞核中检测到。人类 MNDA 的 200 个氨基酸区域与干扰素诱导小鼠基因家族编码的蛋白质中的一个区域惊人地相似，这些基因命名为 Ifi-201、Ifi-202 和 Ifi-203，它们在细胞中不受调节- 或组织特定的时尚。 1.8-kb MNDA mRNA 在 5-prime 非翻译区包含干扰素刺激的反应元件，在暴露于干扰素 α 的人单核细胞中显着上调。 MNDA 位于 FCER1A、APCS、CRP 和 SPTA1 的 2,200 kb 以内。在其表达和/或调节模式中，MNDA 类似于 IFI16，表明这些基因参与了对干扰素的血细胞特异性反应。[RefSeq 提供，2008 年 7 月]

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

MNDA 基因产物(1)

mRNA	Protein	Name
NM_002432.3	NP_002423.1	myeloid cell nuclear differentiation antigen

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23455924	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in B cell receptor signaling pathway	IMP IMP: 通过突变表型推断	17875758	GOA
involved in DNA damage response	IMP IMP: 通过突变表型推断	17875758	GOA
involved in negative regulation of B cell proliferation	IMP IMP: 通过突变表型推断	17875758	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	17875758	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MNDA 蛋白结构

PYRIN

HIN

0
100
200
300
407 a.a.

蛋白主名

其他名称

myeloid cell nuclear differentiation antigen

epididymis secretory sperm binding protein

MNDA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MNDA	P41218	MET	Homo sapiens	P08581	Validated Y2H	32814053
种属内	MNDA	P41218	MET	Homo sapiens	P08581	Y2H Array	32814053
种属内	MNDA	P41218	MET	Homo sapiens	P08581	Y2H Pooling	32814053
种属内	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
种属内	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
种属内	MNDA	P41218	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
种属内	MNDA	P41218	NSD3	Homo sapiens	Q9BZ95	Y2H	23455924
种属内	MNDA	P41218	NSD3	Homo sapiens	Q9BZ95	Anti Tag CoIP	23455924
种属内	MNDA	P41218	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	MNDA	P41218	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	MNDA	P41218	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	MNDA	P41218	A2M	Homo sapiens	P01023	Validated Y2H	32814053
种属内	MNDA	P41218	A2M	Homo sapiens	P01023	Y2H Array	32814053
种属内	MNDA	P41218	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
种属内	MNDA	P41218	TTR	Homo sapiens	P02766	Validated Y2H	32814053
种属内	MNDA	P41218	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
种属内	MNDA	P41218	TTR	Homo sapiens	P02766	Y2H Array	32814053
种属内	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
种属内	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
种属内	MNDA	P41218	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
种属内	MNDA	P41218	PEX1	Homo sapiens	O43933	Y2H Array	32814053
种属内	MNDA	P41218	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
种属内	MNDA	P41218	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Methotrexate-Associated Lymphoproliferation

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

Parkinson Disease 4, Autosomal Dominant

Autosomal Dominant Parkinson Disease 4	PARK4
Parkinson Disease 4, Autosomal Dominant Lewy Body	Parkinson Disease 4
Parkinson'S Disease 4	Autosomal Dominant Lewy Body Parkinson Disease 4
Autosomal Dominant Parkinson'S Disease 4	Parkinson Disease 4 Autosomal Dominant Lewy Body
Parkinson Disease Autosomal Dominant 4	Parkinson Disease Familial Type 4
Parkinson Disease, Type 4

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-160018	BAY-155	Inhibitor	/	否
HY-RS08568	MNDA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	MNDA	VGNC	VGNC:53122
Macaca mulatta	MNDA	VGNC	VGNC:74906

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