MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 6

种属: Homo sapiens

同用名: ASK2; MEKK6; MAPKKK6

基因 ID: 9064 | 基因类型: protein coding

关于 MAP3K6

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,355,184-27,366,961 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶，形成蛋白激酶介导的信号转导级联的一个组成部分。编码的激酶参与血管内皮生长因子 (VEGF) 表达的调节。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP3K6 基因产物(2)

mRNA	Protein	Name
NM_001297609.2	NP_001284538.1	mitogen-activated protein kinase kinase kinase 6 isoform 2
NM_004672.5	NP_004663.3	mitogen-activated protein kinase kinase kinase 6 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	9875215	GOA
enables MAP kinase kinase kinase activity	IDA IDA: 通过直接分析推断	9875215	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	9875215	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19935702	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	9875215	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP3K6 蛋白结构

DUF4071

Pkinase

0
200
400
600
800
1000
1200
1288 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase kinase kinase 6

apoptosis signal-regulating kinase 2

MAP3K6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAP3K6	O95382	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	MAP3K6	O95382	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
种属内	MAP3K6	O95382	SFN	Homo sapiens	P31947	Pull Down	32707033

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer	HDGC
LBC	Familial Diffuse Gastric Cancer
Fdgc	Hereditary Diffuse Gastric Adenocarcinoma
Breast Cancer, Lobular	Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate
DGLBC	Gastric Cancer, Hereditary Diffuse
Gastric Cancer, Familial Diffuse Breast Cancer, Lobular	Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate
E-Cadherin-Associated Hereditary Gastric Cancer	Familial Diffuse Cancer Of Stomach
Hereditary Diffuse Cancer Of Stomach	Gastric Cancer Familial Diffuse
Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate	Cancer, Gastric, Hereditary Diffuse

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Enchondromatosis, Multiple, Ollier Type

Ollier Disease	Enchondromatosis
Dyschondroplasia	Osteochondromatosis
Multiple Cartilaginous Enchondroses	Multiple Enchondromatosis
Enchondromatosis With Haemangiomata	Enchondromatosis, Multiple
Kast'S Syndrome	Ollier'S Syndrome
Enchondromatosis Multiple	ENCHOM
Maffucci Disease	Olliers Disease
Hereditary Multiple Exostoses	Chondromatosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08061	MAP3K6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MAP3K6	VGNC	VGNC:31199
Rattus norvegicus	MAP3K6	RGD	RGD:1304625
Macaca mulatta	MAP3K6	VGNC	VGNC:74496
Felis catus	MAP3K6	VGNC	VGNC:68160
Mus musculus	MAP3K6	MGD	MGI:1855691
Canis familiaris	MAP3K6	VGNC	VGNC:42976
Others	MAP3K6	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

关于 MAP3K6

功能概要

MAP3K6 基因产物(2)

MAP3K6 蛋白结构

MAP3K6 蛋白互作信息

关联疾病

直系同源

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MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

关于 MAP3K6

功能概要

MAP3K6 基因产物(2)

MAP3K6 蛋白结构

MAP3K6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z