2. Gene
  3. PDCD2 - programmed cell death 2 Gene

PDCD2 - programmed cell death 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：程序性细胞死亡 2

种属: Homo sapiens

同用名: RP8; ZMYND7

基因 ID: 5134 | 基因类型: protein coding

关于 PDCD2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:170,575,295-170,584,637 (from NCBI)

This gene has 15 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues.

功能概要

该基因编码一种在多种组织中表达的核蛋白。该基因的表达已被证明受到 B 细胞 CLL/淋巴瘤 6 (BCL6) 的抑制，BCL6 是淋巴结生发中心发育所需的转录抑制因子，表明 BCL6 通过其对该蛋白的作用来调节细胞凋亡。已在 9 号和 12 号染色体上鉴定出多种转录本变体和假基因的可变剪接结果。[RefSeq 提供，2010 年 12 月]

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates Apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

PDCD2 基因产物(7)

mRNA Protein Name
NM_001199461.2 NP_001186390.1 programmed cell death protein 2 isoform 3
NM_001199462.2 NP_001186391.1 programmed cell death protein 2 isoform 4
NM_001199463.2 NP_001186392.1 programmed cell death protein 2 isoform 5
NM_001199464.2 NP_001186393.1 programmed cell death protein 2 isoform 6
NM_001363655.2 NP_001350584.1 programmed cell death protein 2 isoform 7
NM_002598.4 NP_002589.2 programmed cell death protein 2 isoform 1
NM_144781.3 NP_659005.1 programmed cell death protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23382074 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19146857 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
20605493 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
20605493 GOA
involved in positive regulation of hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
22922207 GOA
involved in regulation of hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
22922207 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDCD2 蛋白结构

zf-MYND

zf-MYND: MYND finger (135 - 172)

PDCD2_C

PDCD2_C: Programmed cell death protein 2, C-terminal putative domain (188 - 340)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

programmed cell death protein 2

zinc finger MYND domain-containing protein 7

PDCD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDCD2 Q16342 TBC1D21 Homo sapiens Q8IYX1
Validated Y2H
32296183
种属内
PDCD2 Q16342 RPS2 Homo sapiens P15880
Anti Tag CoIP
33961781
种属内
PDCD2 Q16342 PRKN Homo sapiens O60260
Anti Tag CoIP
19146857
种属内
PDCD2 Q16342 PRKN Homo sapiens O60260
Y2H
19146857
种属间: 跨种属相互作用 种属内: 同种属相互作用

PDCD2 抗体

目录号 产品名 应用 反应物种
HY-P81567 PDCD2 Antibody (YA1312) WB Human, Mouse, Rat

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10191 PDCD2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PDCD2 MGD MGI:104643
Macaca mulatta PDCD2 VGNC VGNC:104419
Felis catus PDCD2 VGNC VGNC:97548
Rattus norvegicus PDCD2 RGD RGD:61887
Bos taurus PDCD2 VGNC VGNC:32660
Canis familiaris PDCD2 VGNC VGNC:44337
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z