2. Gene
  3. SNX33 - sorting nexin 33 Gene

SNX33 - sorting nexin 33 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：排序 nexin 33

种属: Homo sapiens

同用名: SNX30; SH3PX3; SH3PXD3C

基因 ID: 257364 | 基因类型: protein coding

关于 SNX33

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,647,912-75,662,301 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 15 paralogues. Ubiquitous expression in esophagus (RPKM 14.6), ovary (RPKM 14.1) and 24 other tissues.

功能概要

由该基因编码的蛋白质参与细胞骨架重组、囊泡运输、内吞作用和有丝分裂。编码的蛋白质对于有丝分裂期间卵裂沟的产生和有丝分裂的完成至关重要。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

SNX33 基因产物(2)

mRNA Protein Name
NM_001318146.1 NP_001305075.1 sorting nexin-33 isoform 2
NM_153271.2 NP_695003.1 sorting nexin-33 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19487689 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16374509 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cleavage furrow formation IMP
IMP: 通过突变表型推断
22718350 GOA
involved in endocytosis IMP
IMP: 通过突变表型推断
22718350 GOA
involved in endosomal transport IMP
IMP: 通过突变表型推断
22718350 GOA
involved in endosome organization IMP
IMP: 通过突变表型推断
21048941 GOA
involved in macropinocytosis IMP
IMP: 通过突变表型推断
21048941 GOA
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
22718350 GOA
involved in negative regulation of endocytosis IDA
IDA: 通过直接分析推断
18353773 GOA
involved in negative regulation of protein localization to cell surface IDA
IDA: 通过直接分析推断
18419754 GOA
involved in plasma membrane tubulation IDA
IDA: 通过直接分析推断
20964629 GOA
involved in positive regulation of membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
18353773 GOA
involved in positive regulation of protein localization to cell surface IDA
IDA: 通过直接分析推断
18353773 GOA
involved in protein import IDA
IDA: 通过直接分析推断
18353773 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
22718350 GOA
located in cytosol IDA
IDA: 通过直接分析推断
18353773 GOA
located in membrane IDA
IDA: 通过直接分析推断
18353773 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX33 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (7 - 57)

PX

PX: PX domain (232 - 334)

BAR_3_WASP_bdg

BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein (337 - 572)

  • 0
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  • 200
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  • 500
  • 574 a.a.
蛋白主名 其他名称

sorting nexin-33

SH3 and PX domain containing 3

SNX33 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SNX33 Q8WV41 SNX33 Homo sapiens Q8WV41
Anti Tag CoIP
19487689
Intra SNX33 Q8WV41 DNM1 Homo sapiens Q05193
Anti Tag CoIP
33961781
Intra SNX33 Q8WV41 FASLG Homo sapiens P48023
Anti Tag CoIP
19807924
Intra SNX33 Q8WV41 SNX33 Homo sapiens Q8WV41
Pull Down
23085988
Intra SNX33 Q8WV41 DNM1 Homo sapiens Q05193
Anti Tag CoIP
18353773
Intra SNX33 Q8WV41 YWHAG Homo sapiens P61981
Anti Tag CoIP
33961781
Intra SNX33 Q8WV41 NAF1 Homo sapiens Q96HR8
Validated Y2H
32296183
Intra SNX33 Q8WV41 ADAM15 Homo sapiens Q13444
Phage Display
16374509
Intra SNX33 Q8WV41 FASLG Homo sapiens P48023
Phage Display
19807924
Intra SNX33 Q8WV41 WAS Homo sapiens P42768
Anti Tag CoIP
19487689
Intra SNX33 Q8WV41 DNM2 Homo sapiens P50570
Anti Tag CoIP
33961781
Intra SNX33 Q8WV41 SNX9 Homo sapiens Q9Y5X1
Anti Tag CoIP
19487689
Intra SNX33 Q8WV41 SNX9 Homo sapiens Q9Y5X1
Pull Down
23085988
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13542 SNX33 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SNX33 RGD RGD:1307898
Bos taurus SNX33 VGNC VGNC:35110
Canis familiaris SNX33 VGNC VGNC:46640
Macaca mulatta SNX33 VGNC VGNC:77784
Mus musculus SNX33 MGD MGI:2443239
Felis catus SNX33 VGNC VGNC:65556
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