2. Gene
  3. NAF1 - nuclear assembly factor 1 ribonucleoprotein Gene

NAF1 - nuclear assembly factor 1 ribonucleoprotein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核组装因子 1 核糖核蛋白

种属: Homo sapiens

基因 ID: 92345 | 基因类型: protein coding

关于 NAF1

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,103,929-163,166,890 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in testis (RPKM 1.9), endometrium (RPKM 1.8) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性和端粒酶 RNA 结合活性。参与调控含核碱基的化合物代谢过程；核糖体生物合成；和端粒酶全酶复合物组装。位于核质中。含有 sno (s) RNA 的核糖核蛋白复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and Telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and Telomerase holoenzyme complex assembly. Located in nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

NAF1 基因产物(2)

mRNA Protein Name
NM_001128931.2 NP_001122403.1 H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform b
NM_138386.3 NP_612395.2 H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
16618814 GOA
enables RNA binding IPI
IPI: 通过物理相互作用推断
18082603 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16601202 GOA
enables telomerase RNA binding IPI
IPI: 通过物理相互作用推断
18082603 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of positive regulation of telomere maintenance via telomerase IMP
IMP: 通过突变表型推断
27510903 GOA
acts upstream of positive regulation of telomere maintenance via telomere lengthening IMP
IMP: 通过突变表型推断
27510903 GOA
involved in ribosome biogenesis IDA
IDA: 通过直接分析推断
16618814 GOA
involved in telomerase RNA stabilization IMP
IMP: 通过突变表型推断
27510903 GOA
involved in telomerase holoenzyme complex assembly IMP
IMP: 通过突变表型推断
27510903 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IMP
IMP: 通过突变表型推断
27510903 GOA
located in nucleus IMP
IMP: 通过突变表型推断
27510903 GOA
part of sno(s)RNA-containing ribonucleoprotein complex IDA
IDA: 通过直接分析推断
16601202 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAF1 蛋白结构

Gar1

Gar1: Gar1/Naf1 RNA binding region (179 - 329)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
蛋白主名 其他名称

H/ACA ribonucleoprotein complex non-core subunit NAF1

nuclear assembly factor 1 homolog

NAF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NAF1 Q96HR8 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra NAF1 Q96HR8 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra NAF1 Q96HR8 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra NAF1 Q96HR8 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra NAF1 Q96HR8 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra NAF1 Q96HR8 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra NAF1 Q96HR8 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra NAF1 Q96HR8 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
Intra NAF1 Q96HR8 SNX33 Homo sapiens Q8WV41
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 SNX33 Homo sapiens Q8WV41
Anti Tag CoIP
26496610
Intra NAF1 Q96HR8 SNX33 Homo sapiens Q8WV41
Y2H Array
32296183
Intra NAF1 Q96HR8 NOP10 Homo sapiens Q9NPE3
Anti Tag CoIP
26496610
Intra NAF1 Q96HR8 NOP10 Homo sapiens Q9NPE3
Anti Bait CoIP
16601202
Intra NAF1 Q96HR8 DKC1 Homo sapiens O60832
Anti Tag CoIP
26496610
Intra NAF1 Q96HR8 DKC1 Homo sapiens O60832
Anti Bait CoIP
16601202
Intra NAF1 Q96HR8 DKC1 Homo sapiens O60832
Anti Bait CoIP
19179534
Intra NAF1 Q96HR8 HERPUD2 Homo sapiens Q9BSE4
Validated Y2H
32296183
Intra NAF1 Q96HR8 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
Intra NAF1 Q96HR8 MED31 Homo sapiens Q9Y3C7
Validated Y2H
32296183
Intra NAF1 Q96HR8 MED31 Homo sapiens Q9Y3C7
Y2H Array
32296183
Intra NAF1 Q96HR8 MED31 Homo sapiens Q9Y3C7
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra NAF1 Q96HR8 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra NAF1 Q96HR8 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra NAF1 Q96HR8 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra NAF1 Q96HR8 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra NAF1 Q96HR8 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra NAF1 Q96HR8 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra NAF1 Q96HR8 DAB1 Homo sapiens O75553
Y2H Array
25416956
Cross NAF1 Q96HR8 Dkc1 Rattus norvegicus P40615
Anti Bait CoIP
16618814
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09008 NAF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NAF1 MGD MGI:2682306
Macaca mulatta NAF1 VGNC VGNC:75020
Rattus norvegicus NAF1 RGD RGD:1306802
Bos taurus NAF1 VGNC VGNC:54460
Felis catus NAF1 VGNC VGNC:63712
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